POLYADENYLIC ACID POTASSIUM SALT

Base Information

• Chemical Name: POLYADENYLIC ACID POTASSIUM SALT
• CAS No.: 24937-83-5
• Molecular Formula: C10H14N5O7P
• Molecular Weight: 347.22
• Mol file: 24937-83-5.mol

Synonyms:polyadenylic acid potassium salt mr ~7000000;PolyadenylicAcid,M.W.>100,000

Chemical Property of POLYADENYLIC ACID POTASSIUM SALT

Chemical Property:

• Melting Point: 196-200oC
• PSA: 195.88000
• LogP: -1.28180
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of POLYADENYLIC ACID POTASSIUM SALT

There total 234 articles about POLYADENYLIC ACID POTASSIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

adenosine-5'-monophosphate disodium salt (4578-31-8) → 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1)

Guidance literature:

With Dowex 50W×8 resin; In water; at 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.6b00311

Reference yield: 99.0%

5,6-dimethyl-1H-benzotriazole adenine dinucleotide ammonium salt → 5,6-dimethyl-1H-benzotriazole mononucleotide ammonium salt (123499-60-5) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1)

Guidance literature:

With phosphodiesterase; tris hydrochloride; magnesium chloride; In water; at 37 ℃; for 5h; pH: 9.0;

Reference yield: 98.0%

5-methyl-1H-benzotriazole adenine dinucleotide ammonium salt → 5-methyl-1H-benzotriazole mononucleotide ammonium salt (123499-59-2) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1)

Guidance literature:

With phosphodiesterase; tris hydrochloride; magnesium chloride; In water; at 37 ℃; for 10h; pH: 9.0;

upstream raw materials:

cAMP

L-Aspartic acid

[5']inosinic acid

2',3'-di-O-acetyladenosine

Downstream raw materials:

[5']adenylic acid monobenzyl ester

Adenosin-5'-phosphorsaeure-methylester

[5']adenylic acid-(N-benzyloxycarbonyl-L-isoleucine)-anhydride

Ser-AMP

Refernces

• 1、 Takaku. "Studies of phosphorylation. V. 8 Quinolyl dihydrogen phosphate as a phosphorylating reagent in nucleotide synthesis". . p. 2121 - 2123. Retrieved 1977.
• 2、 Ikehara,Otsuka. "Studies on coenzyme analogs. XV. A novel phosphorylating agent, P-diphenyl-, P'-Morpholino pyrophosphorochloridate.". . p. 961 - 967. Retrieved 1963.
• 3、 Taylor, Zane W.,Chamberlain, Alexandra R.,Raushel, Frank M.. "Substrate Specificity and Chemical Mechanism for the Reaction Catalyzed by Glutamine Kinase". . . Retrieved 2018.
• 4、 Florea, Mara,Nau, Werner M.. "Implementation of anion-receptor macrocycles in supramolecular tandem assays for enzymes involving nucleotides as substrates, products, and cofactors". . p. 1033 - 1039. Retrieved 2010.
• 5、 Kaur, Rajinder,Saini, Sanjeev,Kaur, Navneet,Singh, Narinder,Jang, Doo Ok. "Rhodamine-based fluorescent probe for sequential detection of Al3+ ions and adenosine monophosphate in water". . . Retrieved 2020.
• 6、 Huang, Kaisheng,Arabshahi, Abolfazl,Frey, Perry A.. "pH-dependence in the hydrolytic action of the human fragile histidine triad". . p. 5198 - 5206. Retrieved 2005.
• 7、 Lowe, Gordon,Tansley, Gaynor,Cullis, Paul M.. "Synthesis of Adenosine 5'17O>Triphosphate". . p. 595 - 598. Retrieved 1982.
• 8、 Blackburn, G. Michael,Thatcher, Gregory R. J.,Hosseini, Mir Wais,Lehn, Jean-Marie. "EVIDENCE A FOR PROTOPHOSPHATASE CATALYSED CLEAVAGE OF ADENOSINE TRIPHOSPHATE BY A DISSOCIATIVE-TYPE MECHANISM WITHIN A RECEPTOR-SUBSTRATE COMPLEX". . p. 2779 - 2782. Retrieved 1987.
• 9、 Capek, Petr,Pohl, Radek,Hocek, Michal. "Cross-coupling reactions of unprotected halopurine bases, nucleosides, nucleotides and nucleoside triphosphates with 4-boronophenylalanine in water. Synthesis of (purin-8-yl)- and (purin-6-yl)phenylalanines". . p. 2278 - 2284. Retrieved 2006.
• 10、 Dykstra, Holly,Fisk, Chelsea,LaRose, Cassi,Waldhart, Althea,Meng, Xing,Zhao, Gongpu,Wu, Ning. "Mouse long-chain acyl-CoA synthetase 1 is active as a monomer". . . Retrieved 2021.