2,4-Dichloro-7-fluoro-6-Methoxy-quinazoline

Base Information

• Chemical Name: 2,4-Dichloro-7-fluoro-6-Methoxy-quinazoline
• CAS No.: 864292-37-5
• Molecular Formula: C₉H₅Cl₂FN₂O
• Molecular Weight: 247.056
• Mol file: 864292-37-5.mol

Synonyms:2,4-Dichloro-7-fluoro-6-Methoxy-quinazoline;2,4-Dichloro-7-fluoro-6-M...

Chemical Property of 2,4-Dichloro-7-fluoro-6-Methoxy-quinazoline

Chemical Property:

• PSA: 35.01000
• LogP: 3.08430

Purity/Quality:

99%, ^*data from raw suppliers

2,4-Dichloro-7-fluoro-6-methoxyquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-Dichloro-7-fluoro-6-Methoxy-quinazoline

There total 6 articles about 2,4-Dichloro-7-fluoro-6-Methoxy-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-fluoro-6-methoxyquinazoline-2,4(1H,3H)-dione (769158-25-0) → 2,4-dichloro-7-fluoro-6-methoxyquinazoline (864292-37-5)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; for 16h; Heating;

DOI:10.1021/jm070104l

Reference yield:

2-amino-4-fluoro-5-methoxybenzoic acid methyl ester (159768-51-1) → 2,4-dichloro-7-fluoro-6-methoxyquinazoline (864292-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.5 h / 200 °C

2: POCl₃; N,N-dimethylaniline / 16 h / Heating

With N,N-dimethyl-aniline; trichlorophosphate;

DOI:10.1021/jm070104l

Reference yield:

2-bromo-5-fluoro-4-methoxyaniline (445441-58-7) → 2,4-dichloro-7-fluoro-6-methoxyquinazoline (864292-37-5)

Guidance literature:

Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 18 h / Sealed tube

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; dichloromethane / 2 h / 0 - 20 °C

3: dihydrogen peroxide; sodium hydroxide / water; ethanol / 2 h / Reflux

4: N,N-diethylaniline; trichlorophosphate / 4 h / Reflux

With dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.6b01645

upstream raw materials:

7-fluoro-6-methoxyquinazoline-2,4(1H,3H)-dione

2-amino-4-fluoro-5-methoxybenzoic acid methyl ester

2-bromo-5-fluoro-4-methoxyaniline

3-fluoro-4-methoxyaniline

Downstream raw materials:

2-((2-chloro-7-fluoro-6-methoxy-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile

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