Methyl 2-aMino-4-fluoro-5-Methoxybenzoate

Base Information

• Chemical Name: Methyl 2-aMino-4-fluoro-5-Methoxybenzoate
• CAS No.: 159768-51-1
• Molecular Formula: C9H10FNO3
• Molecular Weight: 199.182
• Hs Code.: 2922500090
• Mol file: 159768-51-1.mol

Synonyms:Methyl 2-aMino-4-fluoro-5-Methoxybenzoate;2-Amino-4-fluoro-5-methoxy-benzoic acid methyl ester

Chemical Property of Methyl 2-aMino-4-fluoro-5-Methoxybenzoate

Chemical Property:

• Boiling Point: 311.1±37.0 °C(Predicted)
• PKA: 1.95±0.10(Predicted)
• PSA: 61.55000
• Density: 1.262±0.06 g/cm3(Predicted)
• LogP: 1.78430

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-amino-4-fluoro-5-methoxybenzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-aMino-4-fluoro-5-Methoxybenzoate

There total 5 articles about Methyl 2-aMino-4-fluoro-5-Methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl 4-fluoro-5-methoxy-2-nitrobenzoate (159768-50-0) → 2-amino-4-fluoro-5-methoxybenzoic acid methyl ester (159768-51-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 6h;

DOI:10.1016/j.tetlet.2005.08.123

Reference yield:

sulfuric acid (7664-93-9) + methyl 4-fluoro-3-methoxy-benzoate (74385-37-8) → 2-amino-4-fluoro-5-methoxybenzoic acid methyl ester (159768-51-1) + methyl 4-fluoro-5-methoxy-2-nitrobenzoate (159768-50-0)

Guidance literature:

With nitric acid; palladium; In ethanol;

Reference yield:

4?fluoro-3-methoxybenzoic acid (82846-18-2) → 2-amino-4-fluoro-5-methoxybenzoic acid methyl ester (159768-51-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / H₂SO₄ / 16 h / Heating

2: 62 percent / HNO₃; H₂SO₄ / 0.5 h / 0 - 10 °C

3: 89 percent / hydrogen / Pd/C / ethanol / 6 h / 20 °C

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.tetlet.2005.08.123

upstream raw materials:

methyl 4-fluoro-5-methoxy-2-nitrobenzoate

4?fluoro-3-methoxybenzoic acid

methyl 4-fluoro-3-methoxy-benzoate

sulfuric acid

Downstream raw materials:

4-(3-chloro-4-fluoroanilino)-6-methoxy-7-fluoroquinazoline

4-chloro-7-fluoro-6-methoxyquinazoline

7-fluoro-6-methoxyquinazolin-4-ol

Refernces

• 1、 Harris, Craig S.,Kettle, Jason G.,Williams, Emma J.. "Facile synthesis of 7-amino anilinoquinazolines via direct amination of the quinazoline core". . p. 7381 - 7384. Retrieved 2007/10/03.
• 2、 -. "Quinazoline derivatives". . . Retrieved 2008/06/13.