2,4,6-Trimethylphenylhydrazine hydrochloride

Base Information

• Chemical Name: 2,4,6-Trimethylphenylhydrazine hydrochloride
• CAS No.: 24006-09-5
• Molecular Formula: C₉H₁₄N₂*ClH
• Molecular Weight: 186.684
• European Community (EC) Number: 636-040-6,805-414-2
• Mol file: 24006-09-5.mol

Synonyms:Mesitylhydrazine Hydrochloride;2,4,6-Trimethylphenylhydrazine hydrochloride;76195-82-9;24006-09-5;1-Mesitylhydrazine hydrochloride;Mesitylhydrazine xhydrochloride;MFCD00052268;(2,4,6-trimethylphenyl)hydrazine;hydrochloride;Hydrazine, (2,4,6-trimethylphenyl)-, hydrochloride;2,4,6-Trimethylphenylhydrazine, HCl;(2,4,6-trimethylphenyl)hydrazine Hydrochloride;Mesitylhydrazinexhydrochloride;mesityl hydrazine hydrochloride;SCHEMBL2071013;XFGPCULNJGZRTH-UHFFFAOYSA-N;BDA19582;2,4,6-Trimethylphenylhydrazine HCl;ZB1460;AKOS001476997;CS-W022770;DS-4542;BP-10629;SY044796;SY112215;FT-0609909;EN300-93922;F20470;A838637;A878063;2,4,6-Trimethylphenylhydrazine hydrochloride, 95%;Z56940997;F0001-1932

Chemical Property of 2,4,6-Trimethylphenylhydrazine hydrochloride

Chemical Property:

• PSA: 38.05000
• LogP: 3.47270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 186.0923762
• Heavy Atom Count: 12
• Complexity: 113

Purity/Quality:

95% ^*data from raw suppliers

2,4,6-Trimethylphenylhydrazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)C)NN)C.Cl

Technology Process of 2,4,6-Trimethylphenylhydrazine hydrochloride

There total 2 articles about 2,4,6-Trimethylphenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C19H30N2O4 → mesitylhydrazine hydrochloride (24006-09-5,76195-82-9)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; isopropyl alcohol; for 0.5h; Reflux;

DOI:10.1021/jacs.5b11796

Reference yield: 54.0%

2,4,6-trimethylaniline (88-05-1) → mesitylhydrazine hydrochloride (24006-09-5,76195-82-9)

Guidance literature:

2,4,6-trimethylaniline; With hydrogenchloride; In water; at -5 ℃; for 0.75 - 0.833333h;

With sodium nitrite; In water; for 1 - 1.25h;

With sodium hydroxide; tin(ll) chloride; more than 3 stages;

Reference yield: 98.0%

(4aR,9aS)-3-methoxy-2,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazine (862095-80-5) + mesitylhydrazine hydrochloride (24006-09-5,76195-82-9) → (Z)-2-mesityl-1-((4aR,9aS)-4,4a,9,9a-tetrahydroindeno[2,1b][1,4]oxazin-3(2H)-ylidene)hydrazine hydrochloride (1345817-96-0,955103-23-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; ethyl acetate; at 60 - 100 ℃; for 48h; Heating / reflux;

upstream raw materials:

2,4,6-trimethylaniline

Downstream raw materials:

5-Methylsulfanyl-2-(2,4,6-trimethyl-phenyl)-2H-[1,2,4]triazol-3-ylamine

5-amino-4-carboxamido-3-(methylthio)-1-(2,4,6-trimethylphenyl)pyrazole

(Z)-1-mesityl-2-((4aS,9aR)-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-ylidene)hydrazine hydrochloride

2-mesityl-1-(pyrrolidin-2-ylidene)hydrazinium chloride

Refernces

• 1、 Yatham, Veera Reddy,Harnying, Wacharee,Kootz, Darius,Neud?rfl, J?rg-M.,Schl?rer, Nils E.,Berkessel, Albrecht. "1,4-Bis-Dipp/Mes-1,2,4-Triazolylidenes: Carbene Catalysts That Efficiently Overcome Steric Hindrance in the Redox Esterification of α- And β-Substituted α,β-Enals". supporting information. p. 2670 - 2677. Retrieved 2016/03/12.
• 2、 Struble, Justin R.,Bode, Jeffrey W.,Lian, Yajing,Davies, Huw M. L.. "Synthesis of A A-mesityl substituted aminoindanol-derived triazolium salt: [(5aS,10bR)-5a,10b-Dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2, 4-triazolo[4,3-d]-1,4-oxazinium chloride]". experimental part. p. 362 - 376. Retrieved 2011/05/19.