LEUKOTRIENE B4, METHYL ESTER

Base Information

• Chemical Name: LEUKOTRIENE B4, METHYL ESTER
• CAS No.: 83058-42-8
• Molecular Formula: C₂₁H₃₄O₄
• Molecular Weight: 350.499
• Mol file: 83058-42-8.mol

Synonyms:LEUKOTRIENE B4, METHYL ESTER

Chemical Property of LEUKOTRIENE B4, METHYL ESTER

Chemical Property:

• PSA: 66.76000
• LogP: 4.24670
• Storage Temp.: -20°C

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Hazard Codes: F,T
• Statements: 11
• Safety Statements: 7-16-23-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of LEUKOTRIENE B4, METHYL ESTER

There total 92 articles about LEUKOTRIENE B4, METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(5S,6Z,8E,10E,12R,14Z)-methyl 5,12-bis<(tert-butyldiphenylsilyl)oxy>-6,8,10,14-eicosatetraenoate (90108-36-4) → Methyl (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate (83058-42-8)

Guidance literature:

With pyridine; hydrogen fluoride; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 30 ℃; for 24h;

DOI:10.1021/jo00065a012

Reference yield: 70.0%

(-)-(8E,10E,14Z)-(5S,12R)-methyl 5,12-dihydroxy-8,10,14-eicosatrien-6-ynoate (136693-12-4) → Methyl (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate (83058-42-8)

Guidance literature:

With zinc; In methanol; at 35 ℃; for 15h;

DOI:10.1016/S0040-4020(01)88516-1

Reference yield:

(5S)-5-hydroxy-hept-6-ynoic acid, methyl ester (90108-28-4) → Methyl (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate (83058-42-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / imidazole / dimethylformamide / 35 °C

2: 78 percent / n-butylamine, copper iodide / Pd3)>4 / benzene / 3 h / Ambient temperature

3: Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

4: 85 percent

5: 65 percent / Zn, MeOH / H₂O / 5 h / 30 °C

With 1H-imidazole; methanol; copper(l) iodide; tetrabutyl ammonium fluoride; N-butylamine; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jo00037a044

upstream raw materials:

diazomethane

Leukotriene B

(8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-8,10,14-trien-6-methyl ynoate

ester methylique du 12-O-benzoyl-LTB₄

Downstream raw materials:

Leukotriene B