90108-36-4

Upstream product

• 89682-45-1 (6E,8Z)-10-Bromo-5-(tert-butyl-diphenyl-silanyloxy)-deca-6,8-dienoic acid methyl ester 
• 603-35-0 triphenylphosphine 
• 90108-34-2 (5S,8E,10E,12R)-methyl 5,12-bis<(tert-butyldiphenylsilyl)oxy>-8,10-eicosadiene-6,14-diynoate 
• 628-71-7 1-Heptyne 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 90108-26-2 (2R)-2-<(tert-butyldiphenylsilyl)oxy>-4-decynal 
• 90108-29-5 (5S)-5-t-butyl diphenyl silyloxy-hept-6-ynoic acid, methyl ester 
• 116012-52-3 (2E,4R)-4-<(tert-butyldiphenylsilyl)oxy>-2-dodecen-6-ynal 
• 90108-28-4 (5S)-5-hydroxy-hept-6-ynoic acid, methyl ester 
• 90108-25-1 (E)-(S)-5-(tert-Butyl-diphenyl-silanyloxy)-10-(dimethoxy-phosphoryl)-dec-8-en-6-ynoic acid methyl ester 
• 90132-06-2 5-oxo-7-trimethylsilylhept-6-ynoic acid methyl ester 
• 90108-33-1 (2R)-2-<(tert-butyldiphenylsilyl)oxy>-4-decyn-1-ol 
• 120085-71-4 (S)-5-hydroxy-7-trimethylsilylhept-6-ynoic acid methyl ester 
• 90108-31-9 (E)-(S)-10-Bromo-5-(tert-butyl-diphenyl-silanyloxy)-dec-8-en-6-ynoic acid methyl ester 

Downstream Products

• 70578-51-7 (6E,8Z,10E,14Z)-(S)-5,12-Dihydroxy-icosa-6,8,10,14-tetraenoic acid 
• 70578-51-7 (5S,12S,6E,8Z,10E,14Z)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid 
• 71160-24-2 Leukotriene B 
• 83058-42-8 Methyl (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate 
• 79065-10-4 (6E,8Z,10Z,14Z)-(5S,12S)-5,12-Dihydroxy-icosa-6,8,10,14-tetraenoic acid methyl ester 
• 79389-19-8 LTB_x methyl ester 
• 79065-10-4 (6E,8Z,10Z,14Z)-(5R,12S)-5,12-Dihydroxy-icosa-6,8,10,14-tetraenoic acid methyl ester 
• 90529-28-5 (6E,8Z,10E,14Z)-(5R,12S)-5,12-Dihydroxy-icosa-6,8,10,14-tetraenoic acid methyl ester 
• 85082-09-3 6-((1E,3Z,5E,9Z)-(S)-7-Hydroxy-pentadeca-1,3,5,9-tetraenyl)-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

A GENERAL AND STEREOCONTROLLED TOTAL SYNTHESIS OF LEUKOTRIENE B4 AND ANALOGUES

A new, general, and stereocontrolled total synthesis of leukotriene B4 (1) is disclosed.The application of the methodology to the synthesis of several novel analogues of leukotriene B4 is also described.

SYNTHESIS OF 5S,12S-diHETE (LTBx)

The total synthesis of 5S,12S-diHETE (LTBx) was completed.The Wittig reaction of phosphorane 8 and chiral aldehyde 9 provided the key step to form the C-20 chain.