5-b]pyridine

Base Information

• Chemical Name: 5-b]pyridine
• CAS No.: 1086423-62-2
• Molecular Formula: C₇H₆ClN₃
• Molecular Weight: 167.598
• Hs Code.: 2933990090
• Mol file: 1086423-62-2.mol

Synonyms:7-chloro-2-Methyl-3H-iMidazo[4;7-chloro-2-Methyl-3H-iMidazo[4,5-b]pyridine;4-Chloro-2-methyl-7-azabenzimidazole;7-Chloro-2-methyl-1H-imidazo[4,5-b]pyridine

Chemical Property of 5-b]pyridine

Chemical Property:

• PSA: 41.57000
• LogP: 1.91970
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

7-Chloro-2-methyl-3H-imidazo[4,5-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-b]pyridine

There total 4 articles about 5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-methyl-3H-imidazo[4,5-b]pyridine-4-oxide (1137089-65-6) → 7-chloro-2-methyl-3H-imidazo[4,5-b]pyridine (1086423-62-2)

Guidance literature:

With trichlorophosphate; at 80 - 120 ℃; for 3.25h;

Reference yield:

acetic acid (64-19-7,77671-22-8) + 4-chloro-2,3-diaminopyridine (24484-98-8) → 7-chloro-2-methyl-3H-imidazo[4,5-b]pyridine (1086423-62-2)

Guidance literature:

acetic acid; 4-chloro-2,3-diaminopyridine; With PPA; at 150 ℃; for 1h;

With sodium hydroxide; In water; pH=13;

Reference yield:

methyl-2 imidazo<4,5-b>pyridine (68175-07-5) → 7-chloro-2-methyl-3H-imidazo[4,5-b]pyridine (1086423-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 2.25 h / 20 °C

2: trichlorophosphate / 3.25 h / 80 - 120 °C

With 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In ethyl acetate;

upstream raw materials:

acetic acid

4-chloro-2,3-diaminopyridine

methyl-2 imidazo<4,5-b>pyridine

2-methyl-3H-imidazo[4,5-b]pyridine-4-oxide

Downstream raw materials:

7-chloro-1, 2-dimethyl-1H-benzo[d]imidazole

7-chloro-3-(methoxymethyl)-2-methyl-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-3H-imidazo[4,5-b]pyridine-6-carboxamide

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