Cyclobutanecarboxylic acid, 3-ethyl-3-hydroxy-1-methyl-, cis- (9CI)

Base Information

• Chemical Name: Cyclobutanecarboxylic acid, 3-ethyl-3-hydroxy-1-methyl-, cis- (9CI)
• CAS No.: 286442-90-8
• Molecular Formula: C8H14O3
• Molecular Weight: 158.19496
• Mol file: 286442-90-8.mol

Synonyms:Cyclobutanecarboxylic acid, 3-ethyl-3-hydroxy-1-methyl-, cis- (9CI)

Chemical Property of Cyclobutanecarboxylic acid, 3-ethyl-3-hydroxy-1-methyl-, cis- (9CI)

Chemical Property:

• PSA: 57.53000
• LogP: 1.01220

Purity/Quality:

97% ^*data from raw suppliers

cis-3-Ethyl-3-hydroxy-1-methylcyclobutanecarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclobutanecarboxylic acid, 3-ethyl-3-hydroxy-1-methyl-, cis- (9CI)

There total 2 articles about Cyclobutanecarboxylic acid, 3-ethyl-3-hydroxy-1-methyl-, cis- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1-methyl-3-oxocyclobutane-1-carboxylic acid (286442-89-5) + ethylmagnesium bromide (925-90-6) → cis-3-ethyl-3-hydroxy-1-methylcyclobutanecarboxylic acid (286442-90-8,286443-11-6) + trans-3-ethyl-3-hydroxy-1-methylcyclobutanecarboxylic acid (286443-11-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/S0968-0896(00)00034-1

Reference yield:

1-methyl-3-methylidenecyclobutanecarboxylic acid (286442-86-2) → cis-3-ethyl-3-hydroxy-1-methylcyclobutanecarboxylic acid (286442-90-8,286443-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: O₃ / CH₂Cl₂ / 0.5 h / -78 °C

1.2: 75 percent / Me₂S / CH₂Cl₂ / 20 °C

2.1: 24 percent / tetrahydrofuran / 2 h / 20 °C

With ozone; In tetrahydrofuran; dichloromethane; 1.1: Oxidation / 1.2: Ring cleavage / 2.1: Grignard reaction;

DOI:10.1016/S0968-0896(00)00034-1

Reference yield: 16.0%

cis-3-ethyl-3-hydroxy-1-methylcyclobutanecarboxylic acid (286442-90-8,286443-11-6) + 4-bromo-α-methylbenzylamine hydrochloride → cis-(R)-3-ethyl-3-hydroxy-1-methyl-N-[1-(4-bromophenyl)ethyl]cyclobutanecarboxamide

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/S0968-0896(00)00034-1

upstream raw materials:

1-methyl-3-oxocyclobutane-1-carboxylic acid

ethylmagnesium bromide

1-methyl-3-methylidenecyclobutanecarboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 286442-90-8 Cyclobutanecarboxylic acid, 3-ethyl-3-hydroxy-1-methyl-, cis- (9CI)

Send

Send

Metric Ton KG G Pound L ML

Send

Send