1-Methyl-3-Methylenecyclobutanecarboxylic acid

Base Information

• Chemical Name: 1-Methyl-3-Methylenecyclobutanecarboxylic acid
• CAS No.: 286442-86-2
• Molecular Formula: C7H10O2
• Molecular Weight: 126.1531
• Hs Code.: 2916209090
• Mol file: 286442-86-2.mol

Synonyms:1-Methyl-3-Methylenecyclobutanecarboxylic acid;1-methyl-3-methylidenecyclobutane-1-carboxylic acid

Chemical Property of 1-Methyl-3-Methylenecyclobutanecarboxylic acid

Chemical Property:

• PSA: 37.30000
• LogP: 1.42730

Purity/Quality:

97% ^*data from raw suppliers

1-methyl-3-methylidenecyclobutane-1-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-3-Methylenecyclobutanecarboxylic acid

There total 2 articles about 1-Methyl-3-Methylenecyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-methyl-3-methylenecyclobutane-1-carbonitrile (32082-16-9) → 1-methyl-3-methylidenecyclobutanecarboxylic acid (286442-86-2)

Guidance literature:

With water; potassium hydroxide; In ethanol; Reflux;

Reference yield:

3-methylenecyclobutanecarbonitrile (15760-35-7) → 1-methyl-3-methylidenecyclobutanecarboxylic acid (286442-86-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / -78 °C

1.2: 0.67 h / -78 °C

2.1: potassium hydroxide; water / ethanol / 2.5 h / Reflux

With water; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane;

Reference yield: 75.0%

1-methyl-3-methylidenecyclobutanecarboxylic acid (286442-86-2) → 1-methyl-3-oxocyclobutane-1-carboxylic acid (286442-89-5)

Guidance literature:

1-methyl-3-methylidenecyclobutanecarboxylic acid; With ozone; In dichloromethane; at -78 ℃; for 0.5h;

With dimethylsulfide; In dichloromethane; at 20 ℃;

DOI:10.1016/S0968-0896(00)00034-1

upstream raw materials:

1-methyl-3-methylenecyclobutane-1-carbonitrile

3-methylenecyclobutanecarbonitrile

Downstream raw materials:

1-methyl-3-oxocyclobutane-1-carboxylic acid

cis- and trans-3-ethynyl-3-hydroxy-1-methylcyclobutanecarboxylic acid

cis-3-ethyl-3-hydroxy-1-methylcyclobutanecarboxylic acid

trans-3-ethyl-3-hydroxy-1-methylcyclobutanecarboxylic acid