4-((2-Chloro-4-fluorobenzyl)oxy)-benzene-1-sulfonyl chloride

Base Information

• Chemical Name: 4-((2-Chloro-4-fluorobenzyl)oxy)-benzene-1-sulfonyl chloride
• CAS No.: 1036509-25-7
• Molecular Formula: C13H9Cl2FO3S
• Molecular Weight: 335.183
• Hs Code.: 2909309090
• Mol file: 1036509-25-7.mol

Synonyms:4-((2-Chloro-4-fluorobenzyl)oxy)-benzene-1-sulfonyl chloride;Benzenesulfonyl chloride, 4-[(2-chloro-4-fluorophenyl)methoxy]-

Chemical Property of 4-((2-Chloro-4-fluorobenzyl)oxy)-benzene-1-sulfonyl chloride

Chemical Property:

• PSA: 51.75000
• LogP: 5.06640
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

4-((2-Chloro-4-fluorobenzyl)oxy)-benzene-1-sulfonyl chloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-((2-Chloro-4-fluorobenzyl)oxy)-benzene-1-sulfonyl chloride

There total 3 articles about 4-((2-Chloro-4-fluorobenzyl)oxy)-benzene-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

sodium 4-(2-chloro-4-fluorobenzyloxy)benzenesulfonate (1430072-45-9) → 4-(2-chloro-4-fluorobenzyloxy)benzene-1-sulfonyl chloride (1036509-25-7)

Guidance literature:

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 48.2h; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.12.058

Reference yield:

2-chloro-4-fluorobenzylbromide (45767-66-6) → 4-(2-chloro-4-fluorobenzyloxy)benzene-1-sulfonyl chloride (1036509-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / isopropyl alcohol / 70 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 48.2 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.ejmech.2012.12.058

Reference yield:

sodium p-hydroxybenzenesulfonate (825-90-1) → 4-(2-chloro-4-fluorobenzyloxy)benzene-1-sulfonyl chloride (1036509-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / isopropyl alcohol / 70 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 48.2 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.ejmech.2012.12.058

upstream raw materials:

sodium 4-(2-chloro-4-fluorobenzyloxy)benzenesulfonate

2-chloro-4-fluorobenzylbromide

sodium p-hydroxybenzenesulfonate

Downstream raw materials:

N-(tert-butyldimethylsilyloxy)-2-(4-(2-chloro-4-fluoroben-zyloxy)phenylsulfonamido)acetamide

C₁₅H₁₄ClFN₂O₅S

2-(4-(2-chloro-4-fluorobenzyloxy)phenylsulfonamido)acetic acid

Refernces