Methyl (2E)-2-(N-hydroxyimino)-3-(4-hydroxyphenyl)propanoate

Base Information

• Chemical Name: Methyl (2E)-2-(N-hydroxyimino)-3-(4-hydroxyphenyl)propanoate
• CAS No.: 50563-23-0
• Molecular Formula: C10H11NO4
• Molecular Weight: 209.19864
• Hs Code.: 2928000090
• Mol file: 50563-23-0.mol

Synonyms:Methyl (2E)-2-(N-hydroxyimino)-3-(4-hydroxyphenyl)propanoate

Chemical Property of Methyl (2E)-2-(N-hydroxyimino)-3-(4-hydroxyphenyl)propanoate

Chemical Property:

• PSA: 79.12000
• LogP: 0.93790

Purity/Quality:

97% ^*data from raw suppliers

Methyl (2E)-2-(N-hydroxyimino)-3-(4-hydroxyphenyl)propanoate >97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl (2E)-2-(N-hydroxyimino)-3-(4-hydroxyphenyl)propanoate

There total 5 articles about Methyl (2E)-2-(N-hydroxyimino)-3-(4-hydroxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

tyrosine methyl ester (1080-06-4,3410-66-0,18869-47-1) → methyl-[2-hydroxyimino-3-(4-hydroxyphenyl)]propionate (50563-23-0)

Guidance literature:

With sodium tungstate; dihydrogen peroxide; In ethanol; water; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2005.05.038

Reference yield: 67.0%

L-Tyr-OMe (1080-06-4) → methyl-[2-hydroxyimino-3-(4-hydroxyphenyl)]propionate (50563-23-0)

Guidance literature:

With Oxone; sodium hydrogencarbonate; In water; at 25 ℃; for 1h; pH=8.3;

DOI:10.1039/c3cc42261e

Reference yield:

[2-hydroxyimino-3-(4-hydroxyphenyl)]propionic acid (56401-28-6) + methyl iodide (74-88-4) → methyl-[2-hydroxyimino-3-(4-hydroxyphenyl)]propionate (50563-23-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 4 ℃; for 3h; Cooling with ice;

DOI:10.3390/molecules18033543

upstream raw materials:

tyrosine methyl ester

[2-hydroxyimino-3-(4-hydroxyphenyl)]propionic acid

methyl iodide

4-hydroxyphenylpiruvic acid

Downstream raw materials:

3-(3,5-dibromo-4-hydroxyphenyl)-2-(hydroxyimino)propionic acid

methyl 3-(3,5-dibromo-4-hydroxyphenyl)-2-(hydroxyimino)propionate