diMethylethoxy)carbonyl]aMino]-5-(trifluoroMethyl)-, Methyl ester

Base Information

• Chemical Name: diMethylethoxy)carbonyl]aMino]-5-(trifluoroMethyl)-, Methyl ester
• CAS No.: 209688-24-4
• Molecular Formula: C14H16F3NO4
• Molecular Weight: 319.281
• Hs Code.: 2924299090
• Mol file: 209688-24-4.mol

Synonyms:diMethylethoxy)carbonyl]aMino]-5-(trifluoroMethyl)-, Methyl ester;Benzoic acid, 2-[[(1,1-diMethylethoxy)carbonyl]aMino]-5-(trifluoroMethyl)-, Methyl ester

Chemical Property of diMethylethoxy)carbonyl]aMino]-5-(trifluoroMethyl)-, Methyl ester

Chemical Property:

• PSA: 68.12000
• LogP: 3.85260
• Storage Temp.: 2-8°C

Purity/Quality:

Methyl2-((tert-butoxycarbonyl)amino)-5-(trifluoromethyl)benzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diMethylethoxy)carbonyl]aMino]-5-(trifluoroMethyl)-, Methyl ester

There total 2 articles about diMethylethoxy)carbonyl]aMino]-5-(trifluoroMethyl)-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

methyl 2-Amino-5-trifluoromethylbenzoate (117324-58-0) + di-tert-butyl dicarbonate (24424-99-5) → methyl 5-trifluoromethyl-2-t-butoxycarbonylaminobenzoate (209688-24-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + NaOH-ether + tert.-butyl lithium (594-19-4) + tert-butyl (4-(trifluoromethyl)phenyl)carbamate (141940-37-6) → methyl 5-trifluoromethyl-2-t-butoxycarbonylaminobenzoate (209688-24-4)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran;

Reference yield: 97.0%

methyl 5-trifluoromethyl-2-t-butoxycarbonylaminobenzoate (209688-24-4) + Methyl 4-bromobutyrate (4897-84-1) → 2-[tert-butoxycarbonyl-(3-methoxycarbonyl-propyl)-amino]-5-trifluoromethyl-benzoic acid methyl ester (851045-53-9)

Guidance literature:

With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 6h;

upstream raw materials:

methyl 2-Amino-5-trifluoromethylbenzoate

di-tert-butyl dicarbonate

diazomethane

tert.-butyl lithium

Downstream raw materials:

2-[tert-butoxycarbonyl-(3-methoxycarbonyl-propyl)-amino]-5-trifluoromethyl-benzoic acid methyl ester

methyl 2-Amino-5-trifluoromethylbenzoate