117324-58-0

Basic information

• Product Name: METHYL 2-AMINO-5-(TRIFLUOROMETHYL)BENZOATE
• Synonyms: METHYL 2-AMINO-5-(TRIFLUOROMETHYL)BENZOATE;Benzoic acid, 2-amino-5-(trifluoromethyl)-, methyl ester;2-amino-5-(trifluoromethyl)Benzoic acid methyl ester;Methyl 2-amino-5-(trifluoromethyl)
• CAS NO: 117324-58-0
• Molecular Formula: C₉H₈F₃NO₂
• Molecular Weight: 219.16
• Mol File: 117324-58-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 51-52 °C
• Boiling Point: 265.932 °C at 760 mmHg
• Flash Point: 114.632 °C
• Appearance: White/Solid
• Density: 1.344 g/cm³
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.23±0.10(Predicted)
• CAS DataBase Reference: METHYL 2-AMINO-5-(TRIFLUOROMETHYL)BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-AMINO-5-(TRIFLUOROMETHYL)BENZOATE(117324-58-0)
• EPA Substance Registry System: METHYL 2-AMINO-5-(TRIFLUOROMETHYL)BENZOATE(117324-58-0)

Safety Data

• Hazardous Substances Data: 117324-58-0(Hazardous Substances Data)

Usage

General Description

Methyl 2-amino-5-(trifluoromethyl)benzoate is a chemical compound with the formula C9H8F3NO2. It is an aromatic ester that contains a trifluoromethyl group and an amino group. METHYL 2-AMINO-5-(TRIFLUOROMETHYL)BENZOATE is used in the pharmaceutical industry as a building block for the synthesis of various drugs and medicinal compounds. It is also used in chemical research and as a reagent in organic synthesis. Methyl 2-amino-5-(trifluoromethyl)benzoate is a white crystalline solid with a melting point of 70-72 °C and a boiling point of 232-234 °C. Its molecular structure and properties make it suitable for various applications in the field of chemistry and medicine.

InChI:InChI=1/C9H8F3NO2/c1-15-8(14)6-4-5(9(10,11)12)2-3-7(6)13/h2-4H,13H2,1H3

Upstream product

• 67-56-1 methanol 
• 124-38-9 carbon dioxide 
• 25617-34-9 2,2-dimethyl-N-(4-trifluoromethylphenyl)propanamide 
• 83265-53-6 2-amino-5-(trifluoromethyl)benzoic acid 
• 887144-94-7 Togni's reagent II 
• 134-20-3 2-carbomethoxyaniline 
• 1214373-54-2 2-nitro-5-(trifluoromethyl)benzoic acid 
• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 201230-82-2 carbon monoxide 
• 163444-17-5 2-iodo-4-(trifluoromethyl)aniline 
• 209688-24-4 methyl 5-trifluoromethyl-2-t-butoxycarbonylaminobenzoate 
• 144-55-8 sodium hydrogencarbonate 
• 57946-63-1 4-amino-3-bromobenzotrifluoride 

Downstream Products

• 209688-24-4 methyl 5-trifluoromethyl-2-t-butoxycarbonylaminobenzoate 
• 866831-56-3 methyl 2-cyclopropylcarbonylamino-5-trifluoromethylbenzoate 
• 220107-65-3 2-Amino-5-(trifluoromethyl)benzyl alcohol 
• 83265-53-6 2-amino-5-(trifluoromethyl)benzoic acid 
• 847955-87-7 2-(methylsulfonamido)-5-(trifluoromethyl)benzoic acid 
• 847955-86-6 methyl 2-(methylsulfonamido)-5-(trifluoromethyl)benzoate 
• 1448009-48-0 methyl 2-(3-(N,N-diethylsulfamoyl)benzamido)-5-(trifluoromethyl)benzoate 

Relevant articles and documents

QUINAZOLINE-2,4(1H,3H)-DIONE DERIVATIVES AS TRCP5 MODULATORS FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS

This invention relates to novel Quinazoline-2,4(1H,3H)-dione derivatives of Formula (I): and their use as TRPC5 modulators, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment of TRPC5 receptor mediated disorders or conditions. R1, R2, R3 and R4 have meanings given in the description.

Visible-light-promoted radical C-H trifluoromethylation of free anilines

The trifluoromethyl-substituted anilines are biologically active compounds and useful building blocks. In this communication, we have developed the first visible-light-induced radical trifluoromethylation of free anilines with the commercially available and easily handled Togni reagent at room temperature. The resulting products were successfully transformed into a variety of valuable fluorine-containing molecules and heterocyclic compounds. This protocol provides an economical and powerful route to trifluoromethylated free anilines.

ANILINE DERIVATIVES

The present invention provides a novel compound having a kininogenase-inhibitory action and its pharmaceutical use. The compounds represented by the formulas (A), (B), (C), (E) and (H) : wherein each symbol is as defined in the specification, or a pharmac