4-[(3-Methoxyphenyl)methyl]oxolan-2-one

Base Information

Chemical Name:4-[(3-Methoxyphenyl)methyl]oxolan-2-one
CAS No.:187993-26-6
Molecular Formula:C12H14O3
Molecular Weight:206.241
Hs Code.:
DSSTox Substance ID:DTXSID00447239
Nikkaji Number:J1.178.595F
Mol file:187993-26-6.mol

Synonyms:4-[(3-methoxyphenyl)methyl]oxolan-2-one;187993-26-6;Dihydro-3-[(3-methoxyphenyl)methyl]-2(3H)-furanone;SCHEMBL11310048;DTXSID00447239;4-(3-Methoxybenzyl)tetrahydrofuran-2-one;FT-0667047

Suppliers and Price of 4-[(3-Methoxyphenyl)methyl]oxolan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Dihydro-3-[(3-methoxyphenyl)methyl]-2(3H)-furanone
100mg
$ 1055.00

Medical Isotopes, Inc.
Dihydro-3-[(3-methoxyphenyl)methyl]-2(3H)-furanone
100 mg
$ 1460.00

Total 2 raw suppliers

Chemical Property of 4-[(3-Methoxyphenyl)methyl]oxolan-2-one

Chemical Property:

PSA：35.53000
LogP:1.80080
Solubility.:Dichloromethane, Ethyl Acetate, Methanol
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:206.094294304
Heavy Atom Count:15
Complexity:227

Purity/Quality:

99% ^*data from raw suppliers

Dihydro-3-[(3-methoxyphenyl)methyl]-2(3H)-furanone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC(=C1)CC2CC(=O)OC2
Uses Dihydro-3-[(3-Methoxyphenyl)Methyl]-2(3H)-furanone can be used in the preparation of 4,5-diaryloxazole derivatives as prostaglandin I2 antagonist. Use in the preparation of 4,5-diaryloxazole derivatives as prostaglandin I2 antagonist.

Technology Process of 4-[(3-Methoxyphenyl)methyl]oxolan-2-one

There total 2 articles about 4-[(3-Methoxyphenyl)methyl]oxolan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 96-48-0
4-butanolide

: 874-98-6
1-bromomethyl-3-methoxybenzene

: 187993-26-6
3-(3-methoxybenzyl)dihydrofuran-2(3H)-one

Guidance literature:: 4-butanolide; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

1-bromomethyl-3-methoxybenzene; In tetrahydrofuran; hexane; at -78 - 23 ℃; Inert atmosphere;
DOI:10.1021/acs.orglett.5b02833

Reference yield:

: 187993-25-5
3-[hydroxy(3-methoxyphenyl)methyl]-2-oxotetrahydrofuran

: 187993-26-6
3-(3-methoxybenzyl)dihydrofuran-2(3H)-one

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 10h;

Reference yield:

: 187993-26-6
3-(3-methoxybenzyl)dihydrofuran-2(3H)-one

: C₁₃H₁₆O₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere

1.2: 23 °C / Inert atmosphere

2.1: potassium carbonate / methanol / 23 °C

With diisobutylaluminium hydride; potassium carbonate; In methanol; toluene;
DOI:10.1021/acs.orglett.5b02833