3,4-Difluoro-5-methoxybenzoic acid

Base Information

• Chemical Name: 3,4-Difluoro-5-methoxybenzoic acid
• CAS No.: 887584-98-7
• Molecular Formula: C₈H₆F₂O₃
• Molecular Weight: 188.131
• Mol file: 887584-98-7.mol

Synonyms:3,4-Difluoro-5-methoxybenzoic acid

Chemical Property of 3,4-Difluoro-5-methoxybenzoic acid

Chemical Property:

• Vapor Pressure: 0.000938mmHg at 25°C
• Boiling Point: 290.7°C at 760 mmHg
• Flash Point: 129.6°C
• PSA: 46.53000
• Density: 1.399g/cm³
• LogP: 1.67160
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

3,4-Difluoro-5-methoxybenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Difluoro-5-methoxybenzoic acid

There total 1 articles about 3,4-Difluoro-5-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

carbon dioxide (124-38-9,18923-20-1) + 5-bromo-1,2-difluoro-3-methoxy-benzene (261762-35-0) → 3,4-difluoro-5-methoxybenzoic acid (887584-98-7)

Guidance literature:

5-bromo-1,2-difluoro-3-methoxy-benzene; With iodine; magnesium; In diethyl ether; for 2h; Reflux;

carbon dioxide; In tetrahydrofuran; diethyl ether; at 10 ℃; for 1h;

Reference yield:

3,4-difluoro-5-methoxybenzoic acid (887584-98-7) → 3,4-difluoro-5-methoxybenzyl methanesulfonate

Guidance literature:

Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

With borane-THF; triethylamine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

carbon dioxide

5-bromo-1,2-difluoro-3-methoxy-benzene

Refernces

• 1、 -. "Inhibitors of 17Beta-Hydroxysteroid Dehydrogenases Type 1 and Type 2". Paragraph 0326. . Retrieved 2016/12/12.