Allisartan Isoproxil

Base Information

Chemical Name:Allisartan Isoproxil
CAS No.:947331-05-7
Molecular Formula:C27H29ClN6O5
Molecular Weight:553.017
Hs Code.:

Synonyms:Allisartan Isoproxil

Suppliers and Price of Allisartan Isoproxil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 14 raw suppliers

Chemical Property of Allisartan Isoproxil

Chemical Property:

Melting Point:156 - 157 °C
Boiling Point:745.0±70.0 °C(Predicted)
PKA:4.16±0.10(Predicted)
PSA：134.11000
Density:1.35±0.1 g/cm3(Predicted)
LogP:5.45040

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Clinical Use Allisartan isoproxil, a member of a new class of selective angiotensin II-1 receptor antagonists, was approved by the Chinese Food and Drug Administration (CFDA) for the treatment of hypertension in July 2012.19 At time of publication, there is no trade name associated with this drug. Allisartan was discovered and developed by the Chinese biomedical company Allist Pharmaceuticals. Allisartan isoproxil is a prodrug which is readily hydrolyzed to active metabolite EXP3174, which is also the active metabolite of losartan (des-triphenylmethyl-9).

Technology Process of Allisartan Isoproxil

There total 2 articles about Allisartan Isoproxil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

: 947331-22-8
2-butyl-4-chloro-1-[(2'-(1-triphenylmethyl-1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl]imidazole-5-carboxylic acid 1-[(isopropoxy)carbonyloxy]methyl ester

: 947331-05-7
Allisartan

Guidance literature:: With acetic acid; In ethanol; for 10h; Product distribution / selectivity; Reflux;

Reference yield:

: 35180-01-9
chloromethyl isopropyl carbonate

: 124750-92-1
2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid

: 947331-05-7
Allisartan

Guidance literature:: 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid; With potassium carbonate; In N,N-dimethyl acetamide; at 20 ℃; for 0.333333h;

chloromethyl isopropyl carbonate; In N,N-dimethyl acetamide; at 45 - 50 ℃; for 16h;