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124750-92-1

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Product FOB Price Min.Order Supply Ability Supplier
Exp3174
Cas No: 124750-92-1
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
BLOOM TECH Advanced API/Technology support 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID CAS 124750-92-1
Cas No: 124750-92-1
No Data 1 Gram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
Factory Direct Sales Low Price 99% 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID
Cas No: 124750-92-1
No Data No Data No Data Shaanxi Mingqi Chemical Co., Ltd Contact Supplier
1H-Imidazole-5-carboxylicacid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
Cas No: 124750-92-1
No Data No Data No Data Shandong Hanjiang Chemical Co., Ltd. Contact Supplier
Competitive Price /Losartan carboxylic acid
Cas No: 124750-92-1
No Data 1 Kilogram 100 Kilogram/Week Career Henan Chemical Co Contact Supplier
2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID
Cas No: 124750-92-1
USD $ 1.0-2.0 / Gram 1 Gram 5-10 Metric Ton/Week Hangzhou Weck Chemical Industry Co., Ltd. Contact Supplier
EXP-3174
Cas No: 124750-92-1
No Data 1 Gram 1000 Gram/Week Shanghai BetterBioChem Co., Ltd. Contact Supplier
Losartan Carboxylic Acidwith factory price
Cas No: 124750-92-1
No Data No Data 1 Wuhan Sun-shine Bio-technology Corporation Limited Contact Supplier
Losartan Carboxylic Acid
Cas No: 124750-92-1
No Data 1 Kilogram 100 Kilogram/Day HANGZHOU CLAP TECHNOLOGY CO,.LTD Contact Supplier
1H-Imidazole-5-carboxylicacid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
Cas No: 124750-92-1
No Data No Data 5 Hangzhou J&H Chemical Co., Ltd. Contact Supplier

124750-92-1 Usage

Definition

ChEBI: A biphenylyltetrazole that is losartan with the hydroxymethyl group at position 5 on the imidazole ring replaced with a carboxylic acid.

Chemical Properties

Light-Yellow Solid

Uses

A metabolite of Losartan

124750-92-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names 1H-Imidazole-5-carboxylic acid,2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:124750-92-1 SDS

124750-92-1Synthetic route

2-butyl-4-chloro-1-[2'-(1H-tetrazol-5-yl) 1,1'-biphenyl-methyl]imidazole-5-carboxylic acid ethyl ester
947330-97-4

2-butyl-4-chloro-1-[2'-(1H-tetrazol-5-yl) 1,1'-biphenyl-methyl]imidazole-5-carboxylic acid ethyl ester

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid
124750-92-1

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 90℃; for 20h;90%
cozaar
124750-99-8

cozaar

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid
124750-92-1

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid

Conditions
ConditionsYield
Stage #1: cozaar With potassium permanganate In water at -5 - 50℃; for 16h;
Stage #2: With hydrogenchloride In water pH=2 - 3;
89.1%
Stage #1: cozaar With potassium hydroxide In water at 2℃; for 2h;
Stage #2: With sodium periodate; ruthenium trichloride In water; isopropyl alcohol at 4 - 20℃; for 22h;
Stage #3: With phosphoric acid In water; isopropyl alcohol for 0.5h;
Stage #1: cozaar With ruthenium trichloride; potassium hydroxide; sodium periodate In water at 0℃;
Stage #2: With phosphoric acid In water; isopropyl alcohol at 30℃; for 0.5h;
lorsartan
114798-26-4

lorsartan

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid
124750-92-1

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid

Conditions
ConditionsYield
With pyridine; potassium permanganate; tetrabutyl-ammonium chloride In water; acetone at 40 - 50℃; for 1h; Product distribution / selectivity;78%
With sodium periodate; ruthenium(III) trichloride hydrate; potassium hydroxide In water at 0℃;
Stage #1: lorsartan With sodium periodate; ruthenium (III) chloride monohydrate; potassium hydroxide In water at 0℃;
Stage #2: In water; isopropyl alcohol at 25℃; for 2.5h;
Stage #3: With phosphoric acid In water; isopropyl alcohol at 30℃; for 0.5h;
With cytochrome P450 2C9 Enzymatic reaction;
With cytochrome b5; NADPH In aq. phosphate buffer at 37℃; for 0.75h; Kinetics; Reagent/catalyst; Enzymatic reaction;
losartan potassium
124750-99-8

losartan potassium

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid
124750-92-1

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid

Conditions
ConditionsYield
Stage #1: losartan potassium With pyridine; potassium permanganate; tetrabutyl-ammonium chloride In water; acetone at 40 - 50℃; for 1h;
Stage #2: With hydrogenchloride In water; acetone Product distribution / selectivity;
72%
Stage #1: losartan potassium With potassium hydroxide In water at 2℃; for 2h;
Stage #2: With sodium periodate; ruthenium trichloride In water at 4 - 6.5℃; for 19h;
cozaar
124750-99-8

cozaar

A

2-n-Butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxaldehyde
114798-36-6

2-n-Butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxaldehyde

B

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid
124750-92-1

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid

Conditions
ConditionsYield
With manganese(IV) oxide In water at 80 - 180℃; for 0.833333h; microwave irradiation;A 0.253 mmol
B 64%
With manganese(IV) oxide In water at 80 - 180℃; for 0.25h; microwave irradiation;A 60%
B n/a
2-n-Butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxaldehyde
114798-36-6

2-n-Butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxaldehyde

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid
124750-92-1

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid

Conditions
ConditionsYield
With potassium permanganate; potassium hydroxide In water; N,N-dimethyl-formamide at 20 - 30℃; for 2h; Large scale;
2-n-butyl-5-chloro-3H-imidazole-4-carboxylic acid ethyl ester

2-n-butyl-5-chloro-3H-imidazole-4-carboxylic acid ethyl ester

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid
124750-92-1

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrabutylammomium bromide; sodium hydroxide / toluene / 20 h / 60 °C
2: sodium azide; trimethylamine hydrochloride / toluene; 1-methyl-pyrrolidin-2-one / 43 h / 60 °C
3: sodium hydroxide / ethanol / 20 h / 90 °C
View Scheme
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid
124750-92-1

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrabutylammomium bromide; sodium hydroxide / toluene / 20 h / 60 °C
2: sodium azide; trimethylamine hydrochloride / toluene; 1-methyl-pyrrolidin-2-one / 43 h / 60 °C
3: sodium hydroxide / ethanol / 20 h / 90 °C
View Scheme

124750-92-1Downstream Products

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