1-(4-Methylbenzyl)-1H-benzimidazole-2-carbaldehyde

Base Information

• Chemical Name: 1-(4-Methylbenzyl)-1H-benzimidazole-2-carbaldehyde
• CAS No.: 537010-30-3
• Molecular Formula: C16H14N2O
• Molecular Weight: 250.3
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30359417
• Wikidata: Q82140621
• Mol file: 537010-30-3.mol

Synonyms:537010-30-3;1-(4-METHYLBENZYL)-1H-BENZIMIDAZOLE-2-CARBALDEHYDE;1-(4-methylbenzyl)-1H-benzo[d]imidazole-2-carbaldehyde;1-[(4-methylphenyl)methyl]benzimidazole-2-carbaldehyde;F1216-0175;DTXSID30359417;MFCD04352932;STL570283;AKOS000275473;BS-38056;CS-0331837;FT-0742640;EN300-16692329;SR-01000010812;SR-01000010812-1;1-[(4-methylphenyl)methyl]-1H-1,3-benzodiazole-2-carbaldehyde

Chemical Property of 1-(4-Methylbenzyl)-1H-benzimidazole-2-carbaldehyde

Chemical Property:

• Vapor Pressure: 1.06E-08mmHg at 25°C
• Boiling Point: 461.5°C at 760 mmHg
• Flash Point: 232.9°C
• PSA: 34.89000
• Density: 1.15g/cm³
• LogP: 3.20550
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 250.110613074
• Heavy Atom Count: 19
• Complexity: 312

Purity/Quality:

97% ^*data from raw suppliers

1-(4-methylbenzyl)-1H-benzimidazole-2-carbaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2C=O

Technology Process of 1-(4-Methylbenzyl)-1H-benzimidazole-2-carbaldehyde

There total 6 articles about 1-(4-Methylbenzyl)-1H-benzimidazole-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)methanol → 1-(4-methylbenzyl)-1H-benzo[d]imidazole-2-carbaldehyde (537010-30-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 25 ℃; for 2h;

DOI:10.1016/j.bmc.2021.116352

Reference yield:

2-(Hydroxymethyl)benzimidazole (4856-97-7) → 1-(4-methylbenzyl)-1H-benzo[d]imidazole-2-carbaldehyde (537010-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 1 h / 4 °C

With potassium carbonate; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c8md00278a

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 1‐(4‐methylbenzyl)benzimidazole (46804-13-1) → 1-(4-methylbenzyl)-1H-benzo[d]imidazole-2-carbaldehyde (537010-30-3)

Guidance literature:

1‐(4‐methylbenzyl)benzimidazole; With n-butyllithium; In tetrahydrofuran; at -75 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at 75 ℃; for 1h; Inert atmosphere;

DOI:10.1248/cpb.c12-00342

upstream raw materials:

benzoimidazole

4-Methylbenzyl chloride

N,N-dimethyl-formamide

1‐(4‐methylbenzyl)benzimidazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 537010-30-3 1-(4-METHYLBENZYL)-1H-BENZIMIDAZOLE-2-CARBALDEHYDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send