(E)-4-(2-(2-((1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

Base Information

Chemical Name:(E)-4-(2-(2-((1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine
CAS No.:1394047-70-1
Molecular Formula:C₃₂H₃₇N₉O₃S₂
Molecular Weight:659.836
Hs Code.:

(E)-4-(2-(2-((1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

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Chemical Property of (E)-4-(2-(2-((1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

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Technology Process of (E)-4-(2-(2-((1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

There total 10 articles about (E)-4-(2-(2-((1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1381841-07-1
4-(2-hydrazinyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

: 537010-30-3
1-(4-methylbenzyl)-1H-benzo[d]imidazole-2-carbaldehyde

: 1394047-70-1
(E)-4-(2-(2-((1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

Guidance literature:: With acetic acid; In ethanol; Reflux;
DOI:10.1248/cpb.c12-00342

Reference yield:

: 16234-14-3
2,4-dichlorothieno[3,2-d]pyrimidine

: 1394047-70-1
(E)-4-(2-(2-((1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

Guidance literature:: Multi-step reaction with 7 steps

1: methanol / 1.5 h / 0 - 20 °C

2: n-butyllithium / tetrahydrofuran; hexane / 5 h / -78 - 20 °C / Inert atmosphere

3: sodium tetrahydroborate / methanol / 1 h / -10 °C

4: thionyl chloride; N,N-dimethyl-formamide / 1 h / 20 °C / Reflux

5: N-ethyl-N,N-diisopropylamine / i-Amyl alcohol / 11 h / Reflux

6: hydrazine hydrate / 10 h / 80 °C

7: acetic acid / ethanol / Reflux

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; i-Amyl alcohol; hexane;
DOI:10.1248/cpb.c12-00342

Reference yield:

: 885675-66-1
4-(2-chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]-pyrimidin-4-yl)morpholine

: 1394047-70-1
(E)-4-(2-(2-((1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / 10 h / 80 °C

2: acetic acid / ethanol / Reflux

With hydrazine hydrate; acetic acid; In ethanol;
DOI:10.1248/cpb.c12-00342