4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Base Information

• Chemical Name: 4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
• CAS No.: 6109-35-9
• Molecular Formula: C15H16ClN
• Molecular Weight: 245.74724
• European Community (EC) Number: 966-065-0
• ChEMBL ID: CHEMBL4303544
• Mol file: 6109-35-9.mol

Synonyms:4-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride;6109-35-9;4-phenyl-1,2,3,4-tetrahydroisoquinoline;hydrochloride;CHEMBL4303544;MFCD00673906;AKOS024458621;PD021948;CS-0020945;FT-0673839;EN300-29669;SR-01000597874;SR-01000597874-1;BRD-M10474530-001-02-3;F2167-4366;Z234896751

Chemical Property of 4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property:

• PSA: 12.03000
• LogP: 4.05250
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 245.0971272
• Heavy Atom Count: 17
• Complexity: 220

Purity/Quality:

97% ^*data from raw suppliers

4-Phenyl-1,2,3,4-tetrahydroisoquinolineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1C(C2=CC=CC=C2CN1)C3=CC=CC=C3.Cl
• Uses: An inhibitor of release of dopamine induced by methamphetamine.

Technology Process of 4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

There total 2 articles about 4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-phenyl-1,2,3,4-tetrahydroisoquinoline (75626-12-9) → 1,2,3,4-tetrahydro-4-phenylisoquinoline hydrochloride (6109-35-9)

Guidance literature:

With hydrogenchloride; In diethyl ether;

DOI:10.1016/j.tet.2010.03.074

Reference yield:

2-(o-aminobenzyl)-4-phenyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride (133390-58-6) → 1,2,3,4-tetrahydro-4-phenylisoquinoline hydrochloride (6109-35-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 50 ℃; for 5h; Yield given;

Reference yield:

1,2,3,4-tetrahydro-4-phenylisoquinoline hydrochloride (6109-35-9) + acetyl chloride (75-36-5) → 1-(4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone (151724-11-7)

Guidance literature:

With triethylamine; at 0 ℃;

DOI:10.1021/jm00391a028

upstream raw materials:

2-(o-aminobenzyl)-4-phenyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride

4-phenyl-1,2,3,4-tetrahydroisoquinoline

Downstream raw materials:

1-(4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

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