S-23

Base Information

Chemical Name:S-23
CAS No.:1010396-29-8
Molecular Formula:C18H13ClF4N2O3
Molecular Weight:416.759
Hs Code.:
Mol file:1010396-29-8.mol

Synonyms:S-23;(S)-3-(4-Chloro-3-fluorophenoxy)-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide;(2S)-3-(4-Chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide;S 23 (contraceptive)

Suppliers and Price of S-23

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
S23
25mg
$ 245.00

Sigma-Aldrich
(S)-3-(4-Chloro-3-fluorophenoxy)-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide analytical standard
25mg
$ 159.00

DC Chemicals
S23 >98%
100 mg
$ 450.00

Cayman Chemical
S-23
50mg
$ 294.00

Cayman Chemical
S-23
25mg
$ 159.00

Cayman Chemical
S-23
10mg
$ 88.00

Cayman Chemical
S-23
5mg
$ 49.00

Total 89 raw suppliers

Chemical Property of S-23

Chemical Property:

Melting Point:119-121 °C
Boiling Point:577.1±50.0 °C(Predicted)
PKA:12.04±0.29(Predicted)
PSA：82.35000
Density:1.48±0.1 g/cm3(Predicted)
LogP:4.21108
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

S23 ^*data from reagent suppliers

Safty Information:

Pictogram(s): 19161994
Hazard Codes:Xn
Statements: 22-53

MSDS Files:: SDS file from LookChem

Useful:

Description S-23, the orally bioavailable nonsteroidal SARM, is appreciated by jocks over the world for its one of a kind capacity to improve fit bulk and bone tissue. A more secure option in contrast to anabolic steroid, this particular androgen receptor modulator is incredibly powerful to lose obstinate fat. Considered by numerous individuals as an amazing form of S-4 (Andarine), S-23 is a standout amongst other execution upgrading medications to solidify muscle and increase a grainier stylish look.
Uses S 23 is a selective androgen receptor modulator.
Clinical Use S-23 is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolic to androgenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment.

Technology Process of S-23

There total 3 articles about S-23 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.5%

: 348-60-7
4-chloro-3-fluorophenol

: 206193-17-1
(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

: 1010396-29-8
(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

Guidance literature:: (2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide; With potassium carbonate; for 2h; Reflux;

4-chloro-3-fluorophenol; With potassium carbonate; In isopropyl alcohol; for 3h; Reflux;

Reference yield:

: 512776-95-3
(2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide

: 348-60-7
4-chloro-3-fluorophenol

: 1010396-29-8
(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

Guidance literature:: With potassium carbonate; In butanone; Reflux;
DOI:10.1016/j.bmcl.2008.09.002

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 1010396-29-8
(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / tetrahydrofuran / 3 h / 4 °C / Inert atmosphere

1.2: 20 °C

2.1: potassium carbonate / isopropyl alcohol / 3 h / Reflux

With thionyl chloride; potassium carbonate; In tetrahydrofuran; isopropyl alcohol;