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Basic Information
CAS No.: 1010396-29-8
Name: S-23
Molecular Structure:
Molecular Structure of 1010396-29-8 (S-23)
Formula: C18H13ClF4N2O3
Molecular Weight: 416.759
Synonyms: S-23;(S)-3-(4-Chloro-3-fluorophenoxy)-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide;(2S)-3-(4-Chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide;S 23 (contraceptive)
EINECS: -0
Density: 1.48±0.1 g/cm3(Predicted)
Melting Point: 119-121 °C
Boiling Point: 577.1±50.0 °C(Predicted)
Hazard Symbols: 19161994
Risk Codes: 19161994
PSA: 82.35000
LogP: 4.21108
Related products
Synthetic route
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4-chloro-3-fluorophenol

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(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

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(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: (2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide With potassium carbonate for 2h; Reflux;
Stage #2: 4-chloro-3-fluorophenol With potassium carbonate In isopropyl alcohol for 3h; Reflux;		70.5%
With potassium carbonate In isopropyl alcohol for 3h; Reflux;70.5%
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(2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide

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4-chloro-3-fluorophenol

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(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
With potassium carbonate In butanone Reflux;
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4-amino-2-trifluoromethylbenzonitrile

1010396-29-8

(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: thionyl chloride / tetrahydrofuran / 3 h / 4 °C / Inert atmosphere
1.2: 20 °C
2.1: potassium carbonate / isopropyl alcohol / 3 h / Reflux
View Scheme
1010396-29-8

(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

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N,N-Dimethylcarbamoyl chloride

(S)-1-(4-cyano-3-(trifluoromethyl)anilino)-3-(4-chloro-3-fluorophenoxyl)-2-methyl-1-oxopropyl dimethylcarbamate

Conditions
ConditionsYield
Stage #1: (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃;
Stage #2: N,N-Dimethylcarbamoyl chloride In N,N-dimethyl-formamide; mineral oil at 20℃;		155 g
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(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

124-63-0

methanesulfonyl chloride

(S)-1-(4-cyano-3-(trifluoromethyl)anilino)-3-(4-chloro-3-fluorophenoxyl)-2-methyl-1-oxopropyl methanesulfonate

Conditions
ConditionsYield
Stage #1: (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide With sodium hydride In tetrahydrofuran; mineral oil at 0℃;
Stage #2: methanesulfonyl chloride In tetrahydrofuran; mineral oil at 20℃;
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n-hexanoic anhydride

1010396-29-8

(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

(S)-1-(4-cyano-3-(trifluoromethyl)anilino)-3-(4-chloro-3-fluorophenoxyl)-2-methyl-1-oxopropyl pentanoate

Conditions
ConditionsYield
In pyridine Reflux;70 g
1010396-29-8

(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

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acetic anhydride

(S)-1-(4-cyano-3-(trifluoromethyl)anilino)-3-(4-chloro-3-fluorophenoxyl)-2-methyl-1-oxopropyl acetate

Conditions
ConditionsYield
In pyridine Reflux;0.4 g
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nicotinic anhydride

1010396-29-8

(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

(S)-1-(4-cyano-3-(trifluoromethyl)anilino)-3-(4-chloro-3-fluorophenoxyl)-2-methyl-1-oxopropyl pyridine-3-carboxylate

Conditions
ConditionsYield
In pyridine for 10h; Reflux;100 g
1010396-29-8

(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

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benzoic acid anhydride

(S)-1-(4-cyano-3-(trifluoromethyl)anilino)-3-(4-chloro-3-fluorophenoxyl)-2-methyl-1-oxopropyl benzoate

Conditions
ConditionsYield
In pyridine117 g
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    Address:No 317,Jingling Road,Guali Town,Xiaoshan District

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  • S-23

  • Casno:

    1010396-29-8

    S-23

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

    Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

    Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, s

  •  Shandong Mopai Biotechnology Co., LTD

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-15965530500

    Address:shandong

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  • Factory price S-23 in stock

  • Casno:

    1010396-29-8

    Factory price S-23 in stock

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

    Hennan Boyang chemical is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. In our R&D centre, we have a staff of skilled and experienced research chemists. This has enabled

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    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:af

    Address:henan

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  • New sarms S23// S-23// S 23 CAS NO.1010396-29-8 CAS NO.1010396-29-8

  • Casno:

    1010396-29-8

    New sarms S23// S-23// S 23 CAS NO.1010396-29-8 CAS NO.1010396-29-8

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 7.0-8.0

    1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

    KAISA GROUP INC.is the enterprise which is specialize in manfacturing and exporting avariety of Chemical in China. We have the strong economic base and comprehensive technology.We

  •  KAISA GROUP INC

    United States  |  Contact Details

    Business Type:Trading Company

    Tel:15131197030

    Address:1312 17th Street Suite 1402 Denver CO 80202

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  • S-23

  • Casno:

    1010396-29-8

    S-23

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Capacity: We have our own factory in China with 50,0000mt. yearly capacity.Certificate:We have done ISO, Kosher, Reach to serve our customers better, you can trust our quality.Experience:We have done export for 15 years,we have good reputation in gl

    Gihichem is a professional chemical products manufacturer of nutrition supplements & dietary supplements. 99% purity for insurance the safety and effectiveness of our nutritional i

  •  GIHI CHEMICALS CO.,LIMITED

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-86217390

    Address:No.567 Dengcai Street,Sandun,Westlake District,Hangzhou310030,Zhejiang,China.

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  • S-23

  • Casno:

    1010396-29-8

    S-23

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    1:PRICE-Reasonable competitive price2:AFTER SALES-Efficient and reliable after-sales service3:Professional forwarder,Safety and fast delivery4:CUSTOMIZED-Customized labels and package service116:STORAGE-Enough stock in China warehouseAppearance:Powde

    Dedicated to the Chemical Industry for Over 20 Years Our company offers a variety of products which can meet your multifarious demands. We have adhered to the management principles

  •  Shandong Huashang Chemical Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:13518611179--

    Address:No. 57 Industrial South Road,Jinan pilot Free Trade Zone,Shandong Province,China

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  • S-23

  • Casno:

    1010396-29-8

    S-23

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    factory?direct?sale Application:healing drugs

    Antimex Chemical Limied, was founded in 2001, we are specializing in manufacturing & researching of Active pharmaceutical Ingredients,Veterinary pharm APIs,cosmetic ingredients,and

  •  Antimex Chemical Limied

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:0086-21-50563169

    Address:Room1027,No.Jinyu Road,Pudong

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  • S-23

  • Casno:

    1010396-29-8

    S-23

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

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    Hangzhou Shanyi Biotechnology Co., Ltd. is headquartered in Hangzhou, China. It is a high-tech enterprise specializing in the research and development, production, development, and

  •  Hangzhou Shanyi Biotechnology Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:s-086-18093761022

    Address:Guodu Development Building

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  • S-23

  • Casno:

    1010396-29-8

    S-23

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Natural pigment with great potential as antioxidant has the ability of quenching active oxygen and scavenging free radicals. Application:chemical

    P&K International is a premier international biochemical company specializing in connecting world-class manufacturers with markets and customers across the globe.

  •  P&K INTERNATIONAL PTE. LTD.

    Singapore  |  Contact Details

    Business Type:Other

    Tel:86-137 720-55759

    Address:Singapore

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