2-Amino-N-benzyl-N,3-dimethylbutanamidehydrochloride

Base Information

• Chemical Name: 2-Amino-N-benzyl-N,3-dimethylbutanamidehydrochloride
• CAS No.: 1236262-83-1
• Molecular Formula: C₁₃H₂₀N₂O*ClH
• Molecular Weight: 256.776
• Hs Code.: 2924299090
• Mol file: 1236262-83-1.mol

Synonyms:2-Amino-N-benzyl-N,3-dimethylbutanamidehydrochloride

Chemical Property of 2-Amino-N-benzyl-N,3-dimethylbutanamidehydrochloride

Chemical Property:

• PSA: 46.33000
• LogP: 3.13060

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-N-benzyl-N,3-dimethylbutanamidehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-N-benzyl-N,3-dimethylbutanamidehydrochloride

There total 3 articles about 2-Amino-N-benzyl-N,3-dimethylbutanamidehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-benzyl-2-tert-butoxycarbonylamino-N,3-dimethylbutanamide (143440-14-6) → (S)-2-amino-N-benzyl-N,3-dimethylbutanamide hydrochloride (1120500-69-7,1236262-83-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 1.5h; Inert atmosphere;

DOI:10.1021/ol802887h

Reference yield:

benzyl-methyl-amine (103-67-3) → (S)-2-amino-N-benzyl-N,3-dimethylbutanamide hydrochloride (1120500-69-7,1236262-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 23 °C / Inert atmosphere; Sealed tube

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 1.5 h / 23 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jacs.7b06811

Reference yield:

t-Boc-L-valine (13734-41-3) → (S)-2-amino-N-benzyl-N,3-dimethylbutanamide hydrochloride (1120500-69-7,1236262-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 23 °C / Inert atmosphere; Sealed tube

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 1.5 h / 23 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jacs.7b06811

upstream raw materials:

(S)-N-benzyl-2-tert-butoxycarbonylamino-N,3-dimethylbutanamide

t-Boc-L-valine

benzyl-methyl-amine

Refernces

• 1、 Klausen, Rebekka S.,Jacobsen, Eric N.. "Weak Bronsted acid-thiourea co-catalysis: Enantioselective, catalytic protio-pictet-spengler reactions". supporting information; experimental part. p. 887 - 890. Retrieved 2009/07/25.