3-Methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one

Base Information

• Chemical Name: 3-Methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one
• CAS No.: 6500-62-5
• Molecular Formula: C12H14O2
• Molecular Weight: 190.24
• Hs Code.: 2914509090
• Mol file: 6500-62-5.mol

Synonyms:3-Methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one;3-Methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

Chemical Property of 3-Methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one

Chemical Property:

• PSA: 26.30000
• LogP: 2.60430

Purity/Quality:

97% ^*data from raw suppliers

3-Methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one

There total 9 articles about 3-Methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol (124573-34-8) → 3-methoxybenzosuberan-5-one (6500-62-5)

Guidance literature:

With barium permanganate; In acetonitrile; for 1.25h; Heating;

DOI:10.1055/s-1989-27256

Reference yield: 63.0%

3-hydroxy-6,7,8,9-tetrahydro-5H-benzo(a)cyclohepten-5-one (5454-03-5) + dimethyl sulfate (77-78-1) → 3-methoxybenzosuberan-5-one (6500-62-5)

Guidance literature:

DOI:10.1021/jo01289a045

Reference yield:

7-Methoxy-1-tetralone (6836-19-7) + diazomethyl-trimethyl-silane (18107-18-1) → 3-methoxybenzosuberan-5-one (6500-62-5) + 3-methoxy-5,7,8,9-tetrahydro-6H-benzocyclohepten-6-one (91495-63-5)

Guidance literature:

7-Methoxy-1-tetralone; diazomethyl-trimethyl-silane; With diethylaluminium chloride; In diethyl ether; hexane; dichloromethane; at 0 ℃; for 0.166667h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

upstream raw materials:

3-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol

3-hydroxy-6,7,8,9-tetrahydro-5H-benzo(a)cyclohepten-5-one

dimethyl sulfate

2-hydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one