5454-03-5Relevant articles and documents
A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells
Shie, Jiun-Jie,Liu, Ying-Chih,Hsiao, Jye-Chian,Fang, Jim-Min,Wong, Chi-Huey
, p. 1490 - 1493 (2017/02/05)
A new fluorescence-forming probe, coumOCT, designed by fusing cyclooctyne with a coumarin fluorophore was successfully used for the imaging of azido-glycoconjugates in living HeLa cells. This probe is cell-permeable and generates fluorescence after triazole formation, thus minimizing the background signal and enabling the real-time intracellular imaging of glycoconjugate trafficking.
REACTIVE LABELLING COMPOUNDS AND USES THEREOF
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, (2015/11/16)
Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
REACTIVE LABELLING COMPOUNDS AND USES THEREOF
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, (2015/12/08)
Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
BENZOCYCLOOCTYNE COMPOUNDS AND USES THEREOF
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, (2014/03/25)
Provided are benzocyclooctyne compounds of formula (I). These compounds undergo strain-promoted azide-alkyne cyclo additions (SPAAC) without presence of toxic metal catalysts. The provided compounds are useful for diagnosis and imaging of azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
