4-Acetamidophenylhydrazine hydrochloride

Base Information

• Chemical Name: 4-Acetamidophenylhydrazine hydrochloride
• CAS No.: 40566-92-5
• Molecular Formula: C₈H₁₁N₃O*ClH
• Molecular Weight: 201.656
• Mol file: 40566-92-5.mol

Synonyms:

Chemical Property of 4-Acetamidophenylhydrazine hydrochloride

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Acetamidophenylhydrazine hydrochloride

There total 3 articles about 4-Acetamidophenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-acetamidophenyl)hydrazine-1-carboxylic acid 1,1-dimethylethyl ester → N-(4-hydrazinylphenyl)acetamide hydrochloride (40566-92-5,56745-86-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 15h;

DOI:10.1002/chem.201504010

Reference yield:

4-Acetamido-1-iodobenzene (622-50-4) → N-(4-hydrazinylphenyl)acetamide hydrochloride (40566-92-5,56745-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; caesium carbonate / dimethyl sulfoxide / 22 h / 50 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 15 h / 0 - 20 °C

With hydrogenchloride; copper(l) iodide; caesium carbonate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

DOI:10.1002/chem.201504010

Reference yield:

N-acetyl-p-phenylenediamine (122-80-5) → N-(4-hydrazinylphenyl)acetamide hydrochloride (40566-92-5,56745-86-9)

Guidance literature:

With hydrogenchloride; hydrogen sulfide; tin(ll) chloride; sodium nitrite; Yield given. Multistep reaction; 1.) water, 0 deg C, 30 min, 2.) water, 40 deg C;

upstream raw materials:

N-acetyl-p-phenylenediamine

4-Acetamido-1-iodobenzene

Downstream raw materials:

5-amino-3,3-dimethyl-2-(4-nitrophenyl)-3H-indole

Refernces

• 1、 Van Walree, Cornelis A.,Maarsman, Adriaan W.,Marsman, Albert W.,Flipse, Marinus C.,Jenneskens, Leonardus W.,Smeets, Wilberth J. J.,Spek, Anthony L.. "Electronic and second-order nonlinear optical properties of conformationally locked benzylideneanilines and biphenyls. The effect of conformation on the first hyperpolarizability". . p. 809 - 819. Retrieved 2007/10/03.