622-50-4

Basic information

• Product Name: N-(4-Iodophenyl)acetamide
• Synonyms: 4’-iodo-acetanilid;Acetamide, N-(4-iodophenyl)-;Acetanilide, 4'-iodo-;n-(4-iodophenyl)-acetamid;n-(4-iodophenyl)acetamide;p-Iodoacetanilide;4'-IODOACETANILIDE;4-IODOACETANILIDE
• CAS NO: 622-50-4
• Molecular Formula: C₈H₈INO
• Molecular Weight: 261.06
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;API intermediates;Anilines, Amides & Amines;Iodine Compounds
• Mol File: 622-50-4.mol
• Article Data: 115

Chemical Properties

• Melting Point: 182.0 to 187.0 °C
• Boiling Point: 180°C (rough estimate)
• Appearance: Bluish-gray to purple/Powder
• Density: 1.7396 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 14.38±0.70(Predicted)
• Water Solubility: 182.7mg/L(25 oC)
• CAS DataBase Reference: N-(4-Iodophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Iodophenyl)acetamide(622-50-4)
• EPA Substance Registry System: N-(4-Iodophenyl)acetamide(622-50-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RTECS: AE4285000
• Hazardous Substances Data: 622-50-4(Hazardous Substances Data)

Usage

Chemical Properties

Bluish-grey to purple powder

Upstream product

• 108-24-7 acetic anhydride 
• 540-37-4 p-aminoiodobenzene 
• 103-84-4 Acetanilid 
• 7790-99-0 Iodine monochloride 
• 64-19-7 acetic acid 
• 473-34-7 N,N-dichloro-p-toluenesulfonamide 
• 7553-56-2 iodine 
• 7732-18-5 water 
• 62404-59-5 4-(N-acetyl-N-methylamino)iodobenzene 
• 75-36-5 acetyl chloride 
• 123-54-6 acetylacetone 
• 122-80-5 N-acetyl-p-phenylenediamine 
• 67-64-1 acetone 
• 60-35-5 acetamide 

Downstream Products

• 113337-50-1 (Z)-3-(4-Acetylamino-phenyl)-2-methoxy-acrylic acid methyl ester 
• 143101-60-4 (E)-4-(3-ethoxy-1-oxoprop-2-en-1-yl)acetanilide 
• 4094-39-7 4-(acetamino)phenyl 4-methylphenyl sulfone 
• 130721-59-4 4-methylene-3-(toluene-4-sulfonyl)-1-oxa-3-azaspiro[4.5]decan-2-one 
• 103-84-4 Acetanilid 
• 474966-95-5 N-(2-bromo-4-iodophenyl)acetamide 
• 540-37-4 p-aminoiodobenzene 
• 214360-60-8 N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 
• 62404-59-5 4-(N-acetyl-N-methylamino)iodobenzene 
• 86295-20-7 N-(4-(octylamino)phenyl)acetamide 
• 1167424-36-3 C₁₂H₁₄INO₂S₂ 
• 1241919-84-5 N-(4-iodophenyl)-N-(2-(pyridin-2-yl)phenyl)acetamide 
• 1241919-96-9 N-(4-iodophenyl)-N-(1-methyl-1H-indol-2-yl)acetamide 
• 351-83-7 4'-fluoroacetanilide 

Relevant articles and documents

Room temperature HFIP/Ag-promoted palladium-catalyzed C–H functionalization of benzothiazole with iodoarenes

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodoarenes under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted sele

Sulfated polyborate-H2O assisted tunable activation of N-iodosuccinimide for expeditious mono and diiodination of arenes

Owing to both Lewis and Bronsted acid active sites on sulfated polyborate under homogenous conditions, we were keen on developing iodination protocol of arenes that can meet the requirement of regioselectivity and higher yield. The sulfated polyborate activates N-iodosuccinimide for mono iodination of highly activated substrates viz. phenols, anilines under anhydrous condition. Water tunes sulfated polyborate to generate more Bronsted acid sites resulting in rapid activation of NIS for diiodination. The protocol was equally applicable to diiodination of 4-hydroxyphenylacetic acid to synthesize 4-hydroxy-3,5-diiodophenylacetic acid, an intermediate of tiratricol, a thyroid treatment drug. This protocol was further integrated via one-pot sequential iodination and Sonogashira coupling to synthesize aryl acetylenes, building blocks for the synthesis of a variety of specialty chemicals, API, and natural products.

Magnetically recyclable silica-coated ferrite magnetite-K10montmorillonite nanocatalyst and its applications in O, N, and S-acylation reaction under solvent-free conditions

Novel silica-coated ferrite nanoparticles supported with montmorillonite (K10) have been prepared successfully by using a simple impregnation method. Further, these nanoparticles were characterized by using different analytical methods like FT-IR, PXRD, EDS, and FE-SEM techniques. In addition, these nanoparticles have been explored for their catalytic activity for the O, N, and S-acylation reactions under solvent-free conditions which gave moderate to excellent yields in a much shorter reaction time. Moreover, these nanoparticles could easily be separated out from the reaction medium after the reaction completion by using an external magnetic field and have been re-used for 10 cycles without any significant loss of the catalytic activity.