3-Azetidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-3-[(3-ethoxy-1,3-dioxopropyl)aMino]-, Methyl ester

Base Information

• Chemical Name: 3-Azetidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-3-[(3-ethoxy-1,3-dioxopropyl)aMino]-, Methyl ester
• CAS No.: 1105662-91-6
• Molecular Formula: C₁₆H₂₆N₂O₇
• Molecular Weight: 358.392
• Mol file: 1105662-91-6.mol

Synonyms:3-Azetidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-3-[(3-ethoxy-1,3-dioxopropyl)aMino]-, Methyl ester

Chemical Property of 3-Azetidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-3-[(3-ethoxy-1,3-dioxopropyl)aMino]-, Methyl ester

Chemical Property:

• Boiling Point: 495.2±40.0 °C(Predicted)
• PKA: 12.67±0.46(Predicted)
• PSA: 114.73000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 1.38660

Purity/Quality:

≥95% ^*data from raw suppliers

1-[(1,1-Dimethylethoxy)carbonyl]-3-[(3-ethoxy-1,3-dioxopropyl)amino]-3-azetidineaceticAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Azetidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-3-[(3-ethoxy-1,3-dioxopropyl)aMino]-, Methyl ester

There total 2 articles about 3-Azetidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-3-[(3-ethoxy-1,3-dioxopropyl)aMino]-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-amino-3-(2-methoxy-2-oxo-ethyl)azetidine-1-carboxylate (1105662-89-2) + ethyl chlorocarbonylacetate (36239-09-5) → tert-butyl 3-(3-ethoxy-3-oxopropanamido)-3-(2-methoxy-2-oxoethyl)azetidine-1-carboxylate (1105662-91-6)

Guidance literature:

With triethylamine; In dichloromethane; at -5 - 20 ℃; for 0.333333h;

Reference yield:

→ tert-butyl 3-(3-ethoxy-3-oxopropanamido)-3-(2-methoxy-2-oxoethyl)azetidine-1-carboxylate (1105662-91-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

tert-butyl 3-amino-3-(2-methoxy-2-oxo-ethyl)azetidine-1-carboxylate

ethyl chlorocarbonylacetate

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS USEFUL AS MK2 INHIBITORS". Page/Page column 48. . Retrieved 2009/03/07.