5,6-DiMethylnicotinaldehyde

Base Information

• Chemical Name: 5,6-DiMethylnicotinaldehyde
• CAS No.: 1174028-17-1
• Molecular Formula: C8H9NO
• Molecular Weight: 135.16316
• Hs Code.: 2933399090
• Mol file: 1174028-17-1.mol

Synonyms:5,6-DiMethylnicotinaldehyde;5,6-Dimethyl-pyridine-3-carbaldehyde

Chemical Property of 5,6-DiMethylnicotinaldehyde

Chemical Property:

• Boiling Point: 242.9±35.0 °C(Predicted)
• PKA: 4.44±0.20(Predicted)
• PSA: 29.96000
• Density: 1.065±0.06 g/cm3(Predicted)
• LogP: 1.51090
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

5,6-Dimethylpyridine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-DiMethylnicotinaldehyde

There total 4 articles about 5,6-DiMethylnicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-Lutidine (583-61-9) → 3-bromo-5,6-dimethylpyridine (27063-90-7) + 5,6-dimethylpyridine-3-carboxaldehyde (1174028-17-1)

Guidance literature:

With bromine;

Reference yield:

(5,6-Dimethyl-[3]pyridyl)-methanol (857146-29-3) → 5,6-dimethylpyridine-3-carboxaldehyde (1174028-17-1)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; Heating;

DOI:10.1021/jm00123a012

Reference yield:

5,6-dimethylpyridine-3-carboxylic acid (757903-81-4) → 5,6-dimethylpyridine-3-carboxaldehyde (1174028-17-1)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. H₂SO₄ / Heating

2: LiAlH₄ / diethyl ether / Heating

3: MnO₂ / CH₂Cl₂ / Heating

With manganese(IV) oxide; lithium aluminium tetrahydride; sulfuric acid; In diethyl ether; dichloromethane;

DOI:10.1021/jm00123a012

upstream raw materials:

(5,6-Dimethyl-[3]pyridyl)-methanol

5,6-dimethylpyridine-3-carboxylic acid

ethyl 5,6-dimethyl-3-pyridinecarboxylate

2,3-Lutidine

Downstream raw materials:

(E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(5,6-dimethyl-pyridin-3-yl)-acrylamide

Refernces

• 1、 Nishikawa,Shindo,Ishii,Nakamura,Kon,Uno. "Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides". . p. 583 - 593. Retrieved 2007/10/02.