Carbamic acid, [(1alpha,5alpha,6alpha)-3-hydroxybicyclo[3.1.0]hex-6-yl]-, 1,1-dimethylethyl

Base Information

Chemical Name:Carbamic acid, [(1alpha,5alpha,6alpha)-3-hydroxybicyclo[3.1.0]hex-6-yl]-, 1,1-dimethylethyl
CAS No.:505028-25-1
Molecular Formula:C₁₁H₁₉NO₃
Molecular Weight:213.277
Hs Code.:
Mol file:505028-25-1.mol

Synonyms:Carbamic acid, [(1alpha,5alpha,6alpha)-3-hydroxybicyclo[3.1.0]hex-6-yl]-, 1,1-dimethylethyl

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [(1alpha,5alpha,6alpha)-3-hydroxybicyclo[3.1.0]hex-6-yl]-, 1,1-dimethylethyl

Chemical Property:

Boiling Point:339.4±31.0 °C(Predicted)
PKA:12.36±0.40(Predicted)
PSA：60.77000
Density:1.15±0.1 g/cm3(Predicted)
LogP:1.53420

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1alpha,5alpha,6alpha)-3-hydroxybicyclo[3.1.0]hex-6-yl]-, 1,1-dimethylethyl

There total 2 articles about Carbamic acid, [(1alpha,5alpha,6alpha)-3-hydroxybicyclo[3.1.0]hex-6-yl]-, 1,1-dimethylethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-hydroxybicyclo[3.1.0]hexane-6-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 505028-25-1
tert-butyl (3-hydroxybicyclo[3.1.0]hexan-6-yl)carbamate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In toluene; at 80 ℃;

Reference yield:

: 26786-36-7
3-hydroxybicyclo[3.1.0]hexane-6-carboxylic acid ethyl ester

: 505028-25-1
tert-butyl (3-hydroxybicyclo[3.1.0]hexan-6-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / ethanol / 2 h / 20 °C

2: diphenyl phosphoryl azide; triethylamine / toluene / 80 °C

With diphenyl phosphoryl azide; water; triethylamine; sodium hydroxide; In ethanol; toluene;

Reference yield: 5.0%

: (S)-3-(methylcarbamoyl)-1-(1-phenylethyl)-1H-pyrazole-5-carboxylic acid

: 505028-25-1
tert-butyl (3-hydroxybicyclo[3.1.0]hexan-6-yl)carbamate

: N⁵-((1R,3R,5S,6r)-3-hydroxybicyclo[3.1.0]hexan-6-yl)-N³-methyl-1-((S)-1-phenylethyl)-1H-pyrazole-3,5-dicarboxamide

Guidance literature:: tert-butyl (3-hydroxybicyclo[3.1.0]hexan-6-yl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

(S)-3-(methylcarbamoyl)-1-(1-phenylethyl)-1H-pyrazole-5-carboxylic acid; With triethylamine; HATU; In dichloromethane; at 20 ℃; for 2h;