2-Bromo-4-methyl-nicotinic acid ethyl ester

Base Information

Chemical Name:2-Bromo-4-methyl-nicotinic acid ethyl ester
CAS No.:65996-17-0
Molecular Formula:C9H10BrNO2
Molecular Weight:244.0852
Hs Code.:2933399090
DSSTox Substance ID:DTXSID00555565
Wikidata:Q82436952
Mol file:65996-17-0.mol

Synonyms:2-Bromo-4-methyl-nicotinic acid ethyl ester;65996-17-0;ethyl 2-bromo-4-methylnicotinate;ethyl 2-bromo-4-methylpyridine-3-carboxylate;2-bromo-4-methyl-3-pyridinecarboxylic acid ethyl ester;MFCD16610942;SCHEMBL1260935;ethyl2-bromo-4-methylnicotinate;DTXSID00555565;AKOS015838681;AS-5619;SY283657;CS-0103544

Suppliers and Price of 2-Bromo-4-methyl-nicotinic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
2-Bromo-4-methyl-nicotinic acid ethyl ester 95+%
1g
$ 466.00

Crysdot
Ethyl2-Bromo-4-methylnicotinate 95+%
1g
$ 461.00

Chemenu
Ethyl2-Bromo-4-methylnicotinate 95%
1g
$ 436.00

Atlantic Research Chemicals
Ethyl2-Bromo-4-methylnicotinate 95%
1gm:
$ 275.70

Atlantic Research Chemicals
Ethyl2-Bromo-4-methylnicotinate 95%
250mgs:
$ 137.85

Ambeed
Ethyl2-Bromo-4-methylnicotinate 98+%
1g
$ 136.00

Ambeed
Ethyl2-Bromo-4-methylnicotinate 98+%
250mg
$ 55.00

Ambeed
Ethyl2-Bromo-4-methylnicotinate 98+%
100mg
$ 37.00

Advanced Chemicals Intermediatesced Chemicals Intermediates
2-Bromo-4-methyl-nicotinicacidethylester 95%+
1g
$ 282.75

Acints
2-Bromo-4-methyl-nicotinicacidethylester 95%+
1g
$ 282.75

Total 9 raw suppliers

Chemical Property of 2-Bromo-4-methyl-nicotinic acid ethyl ester

Chemical Property:

Boiling Point:288.2±35.0 °C(Predicted)
PKA:-0.49±0.18(Predicted)
PSA：39.19000
Density:1.439±0.06 g/cm3(Predicted)
LogP:2.32920
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:242.98949
Heavy Atom Count:13
Complexity:187

Purity/Quality:

99%, ^*data from raw suppliers

2-Bromo-4-methyl-nicotinic acid ethyl ester 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(C=CN=C1Br)C

Technology Process of 2-Bromo-4-methyl-nicotinic acid ethyl ester

There total 5 articles about 2-Bromo-4-methyl-nicotinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (2Z,4E)-ethyl 2-cyano-5-(dimethylamino)-3-methylpenta-2,4-dienoate

: 65996-17-0
ethyl 2-bromo-4-methylnicotinic acid

Guidance literature:: With hydrogen bromide; acetic acid; at 40 - 55 ℃; for 15h;

Reference yield:

: 65996-11-4
1-carbethoxy-1-cyano-2-methyl-4-dimethylamino-1,4-butadiene

: 65996-17-0
ethyl 2-bromo-4-methylnicotinic acid

Guidance literature:: 1-carbethoxy-1-cyano-2-methyl-4-dimethylamino-1,4-butadiene; With hydrogen bromide; acetic acid; at 40 - 55 ℃; for 2h; under 760.051 Torr;

With sodium carbonate; In water; under 760.051 Torr; Cooling with ice;

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 65996-17-0
ethyl 2-bromo-4-methylnicotinic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine; acetic acid / 24 h / 760.05 Torr / Reflux

2.1: ethanol / 6 h / 760.05 Torr / Reflux

3.1: hydrogen bromide; acetic acid / 2 h / 40 - 55 °C / 760.05 Torr

3.2: 760.05 Torr / Cooling with ice

With piperidine; hydrogen bromide; acetic acid; In ethanol;