2-Bromo-4-methyl-nicotinic acid

Base Information

Chemical Name:2-Bromo-4-methyl-nicotinic acid
CAS No.:65996-07-8
Molecular Formula:C7H6BrNO2
Molecular Weight:216.034
Hs Code.:2933399090
DSSTox Substance ID:DTXSID90597757
Wikidata:Q82493396

Synonyms:2-Bromo-4-methyl-nicotinic acid;65996-07-8;2-Bromo-4-methylnicotinic acid;2-bromo-4-methylpyridine-3-carboxylic acid;2-Bromo-4-methyl-3-pyridinecarboxylic acid;2-Bromo-4-methylnicotinicacid;SCHEMBL1261411;DTXSID90597757;XRYGHOZBHDBJEJ-UHFFFAOYSA-N;MFCD13189139;AKOS015834836;AB67819;AS-5620;DB-364801;CS-0372945;H10306

Suppliers and Price of 2-Bromo-4-methyl-nicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Bromo-4-methylnicotinicAcid
50mg
$ 90.00

TRC
2-Bromo-4-methylnicotinicAcid
100mg
$ 155.00

Oakwood
2-Bromo-4-methyl-nicotinicacid 95%
1g
$ 450.00

Matrix Scientific
2-Bromo-4-methyl-nicotinic acid 95+%
1g
$ 360.00

Matrix Scientific
2-Bromo-4-methyl-nicotinic acid 95+%
5g
$ 1312.00

Crysdot
2-Bromo-4-methylnicotinicacid 95+%
1g
$ 842.00

Chemenu
2-Bromo-4-methyl-nicotinicacid 95%
1g
$ 795.00

Atlantic Research Chemicals
2-Bromo-4-methylnicotinicacid 95%
1gm:
$ 144.92

American Custom Chemicals Corporation
2-BROMO-4-METHYLNICOTINIC ACID 95.00%
5MG
$ 500.60

AK Scientific
2-Bromo-4-methylnicotinicacid
5g
$ 1821.00

Total 13 raw suppliers

Chemical Property of 2-Bromo-4-methyl-nicotinic acid

Chemical Property:

PSA：50.19000
LogP:1.85070
Storage Temp.:2-8°C
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:214.95819
Heavy Atom Count:11
Complexity:163

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-4-methylnicotinicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=NC=C1)Br)C(=O)O

Technology Process of 2-Bromo-4-methyl-nicotinic acid

There total 5 articles about 2-Bromo-4-methyl-nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 124-38-9,18923-20-1
carbon dioxide

: 65996-07-8
2-bromo-4-methyl-3-pyridinecarboxylic acid

Guidance literature:: 2,3-dibromo-4-methylpyridine; With tert.-butyl lithium; In hexanes; diethyl ether; at -78 ℃; for 2h;

carbon dioxide; In hexanes; diethyl ether; at -78 - 20 ℃; for 0.833333h;

With water;

Reference yield:

: 65996-17-0
ethyl 2-bromo-4-methylnicotinic acid

: 65996-07-8
2-bromo-4-methyl-3-pyridinecarboxylic acid

Guidance literature:: ethyl 2-bromo-4-methylnicotinic acid; With water; sodium hydroxide; In 1,4-dioxane; for 12h; under 760.051 Torr; Reflux;

With hydrogenchloride; In water; under 760.051 Torr; pH=1;

Reference yield:

: 759-58-0
ethyl isopropylidenecyanoacetate

: 65996-07-8
2-bromo-4-methyl-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 6 h / 760.05 Torr / Reflux

2.1: hydrogen bromide; acetic acid / 2 h / 40 - 55 °C / 760.05 Torr

2.2: 760.05 Torr / Cooling with ice

3.1: sodium hydroxide; water / 1,4-dioxane / 12 h / 760.05 Torr / Reflux

3.2: 760.05 Torr / pH 1

With water; hydrogen bromide; acetic acid; sodium hydroxide; In 1,4-dioxane; ethanol;