2-acetyl-cyclohexanone

Base Information

• Chemical Name: 2-acetyl-cyclohexanone
• CAS No.: 125117-37-5
• Molecular Formula: C₈H₁₂O₂
• Molecular Weight: 140.182
• Mol file: 125117-37-5.mol

Synonyms:2-ACETYLCYCLOHEXANONE

Chemical Property of 2-acetyl-cyclohexanone

Chemical Property:

• PKA: pK1: 14.1 (25°C)
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform, Ethyl Acetate

Purity/Quality:

98%min ^*data from raw suppliers

2-Acetylcyclohexanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Acetylcyclohexanone is used in the synthesis of 1-(pyridyl)ethanol derivatives that can reduce keto-esters and ketones. Also used in the synthesis of phenothiazine derivatives that can inhibit protein farnesyltransferase molecules and some that show anti-proliferative activity.

Technology Process of 2-acetyl-cyclohexanone

There total 36 articles about 2-acetyl-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + acetic anhydride (108-24-7) → 2-acetylcyclohexanone (874-23-7,125117-37-5)

Guidance literature:

With tetrachlorosilane; zinc(II) chloride; In dichloromethane; at 25 ℃; for 5h;

DOI:10.1080/104265090507920

Reference yield: 81.0%

3-allylacetylacetone (10151-22-1) → 2-acetylcyclohexanone (874-23-7,125117-37-5)

Guidance literature:

dichloro bis(acetonitrile) palladium(II); In 1,4-dioxane; at 20 ℃; for 16h;

DOI:10.1021/ja011764x

Reference yield: 72.0%

4-cyclohexen-1-ylmorpholine (670-80-4) + acetyl chloride (75-36-5) → 2-acetylcyclohexanone (874-23-7,125117-37-5)

Guidance literature:

4-cyclohexen-1-ylmorpholine; acetyl chloride; With triethylamine; In toluene; at 20 - 35 ℃;

With hydrogenchloride; water; In toluene; for 1h; Reflux;

upstream raw materials:

Ketene

cyclohexanone N-cyclohexylimine

1-(1-Cyclohexen-1-yl)pyrrolidine

acetic anhydride

Downstream raw materials:

4-methyl-5,6,7,8-tetrahydro-quinazolin-2-ylamine

4-methyl-2-phenyl-5,6,7,8-tetrahydro-quinazoline

4-methyl-5,6,7,8-tetrahydroquinazoline

2-Acetyl-2-phenylselenocyclohexanon