{3-[3-(Trifluoromethyl)pyridin-2-yl]phenyl}methanol

Base Information

• Chemical Name: {3-[3-(Trifluoromethyl)pyridin-2-yl]phenyl}methanol
• CAS No.: 613240-34-9
• Molecular Formula: C₁₃H₁₀F₃NO
• Molecular Weight: 253.224
• DSSTox Substance ID: DTXSID80698762
• Wikidata: Q82629209
• Mol file: 613240-34-9.mol

Synonyms:{3-[3-(Trifluoromethyl)pyridin-2-yl]phenyl}methanol;3-(5-Trifluoromethyl)pyridin-2-yl)benzyl alcohol;DTXSID80698762;1349718-78-0

Chemical Property of {3-[3-(Trifluoromethyl)pyridin-2-yl]phenyl}methanol

Chemical Property:

• PSA: 33.12000
• LogP: 3.25970
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 253.07144843
• Heavy Atom Count: 18
• Complexity: 270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)C2=C(C=CC=N2)C(F)(F)F)CO

Technology Process of {3-[3-(Trifluoromethyl)pyridin-2-yl]phenyl}methanol

There total 2 articles about {3-[3-(Trifluoromethyl)pyridin-2-yl]phenyl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-trifluoromethylpyridine (52334-81-3) + [3-(hydroxymethyl)phenyl]boronic acid (87199-15-3) → [3-(5-Trifluoromethyl-pyridin-2-yl)-phenyl]-methanol (613240-34-9)

Guidance literature:

Reference yield:

→ [3-(5-Trifluoromethyl-pyridin-2-yl)-phenyl]-methanol (613240-34-9)

Guidance literature:

With palladium diacetate; sodium carbonate; triphenylphosphine; In propan-1-ol; water; at 95 ℃; for 2.5h; Inert atmosphere;

Reference yield:

[3-(5-Trifluoromethyl-pyridin-2-yl)-phenyl]-methanol (613240-34-9) → 2-(3-Chloromethyl-phenyl)-5-trifluoromethyl-pyridine

Guidance literature:

upstream raw materials:

2-chloro-5-trifluoromethylpyridine

[3-(hydroxymethyl)phenyl]boronic acid