5,7-Dichloro-8-nitroquinoline

Base Information

• Chemical Name: 5,7-Dichloro-8-nitroquinoline
• CAS No.: 34522-74-2
• Molecular Formula: C₉H₄Cl₂N₂O₂
• Molecular Weight: 243.049
• Mol file: 34522-74-2.mol

Synonyms:5,7-Dichloro-8-nitroquinoline

Chemical Property of 5,7-Dichloro-8-nitroquinoline

Chemical Property:

• Melting Point: 166-167 °C
• Boiling Point: 384.3±37.0 °C(Predicted)
• PKA: -1.43±0.43(Predicted)
• PSA: 58.71000
• Density: 1.593±0.06 g/cm3(Predicted)
• LogP: 3.97300

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-Dichloro-8-nitroquinoline

There total 2 articles about 5,7-Dichloro-8-nitroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5,7-Dichloroquinoline (4964-77-6) → 5,7-dichloro-8-nitro-quinoline (34522-74-2)

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 20 ℃; for 2.5h;

DOI:10.1002/anie.201305615

Reference yield:

3,5-Dichloroaniline (626-43-7) → 5,7-dichloro-8-nitro-quinoline (34522-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide; sulfuric acid / 0.75 h / 110 - 150 °C

2: nitric acid; sulfuric acid / 2.5 h / 0 - 20 °C

With sulfuric acid; nitric acid; sodium iodide; 1: |Skraup Quinoline Synthesis;

DOI:10.1002/anie.201305615

Reference yield:

5,7-dichloro-8-nitro-quinoline (34522-74-2) → N-(5,7-bis-phenylsulfanyl-[8]quinolyl)-acetamide

Guidance literature:

Multi-step reaction with 3 steps

1: methanol

2: SnCl₂; concentrated aqueous HCl

With hydrogenchloride; methanol; tin(ll) chloride;

DOI:10.1021/ja01132a001

upstream raw materials:

5,7-Dichloroquinoline

3,5-Dichloroaniline

Downstream raw materials:

8-nitro-5,7-bis-phenylsulfanyl-quinoline

5,7-dichloro-8-aminoquinoline

5,7-bis-phenylsulfanyl-[8]quinolylamine

Refernces