1-Boc-3-hydroxy-3-(aminomethyl)azetidine

Base Information

• Chemical Name: 1-Boc-3-hydroxy-3-(aminomethyl)azetidine
• CAS No.: 1008526-71-3
• Molecular Formula: C9H18N2O3
• Molecular Weight: 202.254
• Hs Code.: 2933990090
• Mol file: 1008526-71-3.mol

Synonyms:1-Boc-3-hydroxy-3-(aminomethyl)azetidine;1-Boc-3-hydroxy-3-(aMinoM...;tert-Butyl 3-(aminomethyl)-3-hydroxyazetidine-1-carboxylate;1-Boc-3-(aminomethyl)-3-hydroxy-azetidine;1008526-71-3

Chemical Property of 1-Boc-3-hydroxy-3-(aminomethyl)azetidine

Chemical Property:

• Boiling Point: 306.4±27.0 °C(Predicted)
• PKA: 11.84±0.20(Predicted)
• PSA: 75.79000
• Density: 1.194±0.06 g/cm3(Predicted)
• LogP: 0.56510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl3-(Aminomethyl)-3-hydroxyazetidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-3-hydroxy-3-(aminomethyl)azetidine

There total 2 articles about 1-Boc-3-hydroxy-3-(aminomethyl)azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-hydroxy-3-(nitromethyl)azetidin-1-carboxylic acid tert-butyl ester (1008526-70-2) → 3-(aminomethyl)-3-hydroxyazetidin-1-carboxylic acid tert-butyl ester (1008526-71-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; for 16h;

Reference yield:

tert-butyl 3-oxoazetidine-1-carboxylate (398489-26-4) → 3-(aminomethyl)-3-hydroxyazetidin-1-carboxylic acid tert-butyl ester (1008526-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol / 16 h / 20 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 16 h / 20 °C / 775.74 Torr

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; ethanol;

Reference yield: 100.0%

3-(aminomethyl)-3-hydroxyazetidin-1-carboxylic acid tert-butyl ester (1008526-71-3) + 3-(3-(4-chloro-5-fluoropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole (1446358-48-0) → C26H27F2N7O4

Guidance literature:

With triethylamine; In 1,4-dioxane; at 90 ℃;

upstream raw materials:

3-hydroxy-3-(nitromethyl)azetidin-1-carboxylic acid tert-butyl ester

tert-butyl 3-oxoazetidine-1-carboxylate

Downstream raw materials:

6-oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylic acid tert-butyl ester

tert-butyl 7-oxo-5-oxa-2,8-diazaspiro[3.5]nonane-2-carboxylate

tert-butyl 5-oxa-2,8-diazaspiro[3.5]nonane-2-carboxylate

Refernces

• 1、 -. "PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS". Page/Page column 45-46. . Retrieved 2020/12/30.
• 2、 -. "QUINAZOLINE COMPOUND FOR EGFR INHIBITION". Paragraph 0210; 0212. . Retrieved 2019/11/21.