PHENYLETHYL 4-METHYLCAFFEATE

Base Information

• Chemical Name: PHENYLETHYL 4-METHYLCAFFEATE
• CAS No.: 117292-80-5
• Molecular Formula: C18H20O4
• Molecular Weight: 300.35
• Mol file: 117292-80-5.mol

Synonyms:PHENYLETHYL 4-METHYLCAFFEATE

Chemical Property of PHENYLETHYL 4-METHYLCAFFEATE

Chemical Property:

• PSA: 55.76000
• LogP: 3.19990

Purity/Quality:

99% ^*data from raw suppliers

(E)-Phenethyl3-(3-hydroxy-4-methoxyphenyl)acrylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of PHENYLETHYL 4-METHYLCAFFEATE

There total 2 articles about PHENYLETHYL 4-METHYLCAFFEATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.7%

2-phenylethanol (60-12-8) + isoferulic acid (537-73-5,1135-16-6,25522-33-2) → isoferulic acid phenethyl ester (117292-80-5)

Guidance literature:

With thionyl chloride; at 65 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jf500464k

Reference yield: 57.2%

2-phenylethanol (60-12-8) + trans-3-hydroxy-4-methoxycinnamic acid (537-73-5) → 2-phenylethyl (E)-3-(3-hydroxy-4-methoxyphenyl)acrylate (117292-80-5)

Guidance literature:

With ytterbium(III) triflate; In nitromethane; at 120 ℃; for 1h;

DOI:10.3184/174751914X14146000527920

upstream raw materials:

2-phenylethanol

trans-3-hydroxy-4-methoxycinnamic acid

isoferulic acid

Refernces

• 1、 Shi, Haiming,Xie, Dongsheng,Yang, Ruoling,Cheng, Yaqian. "Synthesis of caffeic acid phenethyl ester derivatives, and their cytoprotective and neuritogenic activities in PC12 cells". . p. 5046 - 5053. Retrieved 2015/04/22.