2-Mehtyl-6-[bis(tert-butoxycarbonyl)aMino]-4-chloropyriMidine

Base Information

• Chemical Name: 2-Mehtyl-6-[bis(tert-butoxycarbonyl)aMino]-4-chloropyriMidine
• CAS No.: 1350918-95-4
• Molecular Formula: C₁₅H₂₂ClN₃O₄
• Molecular Weight: 343.81
• Hs Code.: 2933599590
• Mol file: 1350918-95-4.mol

Synonyms:2-Mehtyl-6-[bis(tert-butoxycarbonyl)aMino]-4-chloropyriMidine;2-Methyl-6-[bis(tert-butoxycarbonyl)-amino]-4-chloropyrimidine;6-[Bis(Boc)amino]-4-chloro-2-methylpyrimidine

Chemical Property of 2-Mehtyl-6-[bis(tert-butoxycarbonyl)aMino]-4-chloropyriMidine

Chemical Property:

• PSA: 81.62000
• LogP: 4.11500

Purity/Quality:

98%min ^*data from raw suppliers

6-[Bis(Boc)amino]-4-chloro-2-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-[Bis(Boc)amino]-4-chloro-2-methylpyrimidine is a useful reactant for the preparation of thiazolopyridines as TYK2 inhibitors.

Technology Process of 2-Mehtyl-6-[bis(tert-butoxycarbonyl)aMino]-4-chloropyriMidine

There total 3 articles about 2-Mehtyl-6-[bis(tert-butoxycarbonyl)aMino]-4-chloropyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-amino-6-chloro-2-methylpyrimidine (1749-68-4) → (6-chloro-2-methylpyrimidin-4-yl)-bis-carbamic acid tert-butylester (1350918-95-4)

Guidance literature:

4-amino-6-chloro-2-methylpyrimidine; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.25h;

With di-tert-butyl dicarbonate; at 20 ℃; for 18h;

Reference yield: 100.0%

→ (6-chloro-2-methylpyrimidin-4-yl)-bis-carbamic acid tert-butylester (1350918-95-4)

Guidance literature:

Reference yield: 73.0%

4-amino-6-chloro-2-methylpyrimidine (1749-68-4) + di-tert-butyl dicarbonate (24424-99-5) → (6-chloro-2-methylpyrimidin-4-yl)-bis-carbamic acid tert-butylester (1350918-95-4)

Guidance literature:

With dmap; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

upstream raw materials:

4-amino-6-chloro-2-methylpyrimidine

di-tert-butyl dicarbonate

Downstream raw materials:

{6-[2-(2-chloro-6-cyanophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]2-methylpyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

{6-[2-(2-chloro-6-cyano-4-fluorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-2-methylpyrimidin-4-yl}bis-carbamic acid tert-butyl ester

{6-[2-(2-chloro-6-fluorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-2-methylpyrimidin-yl}bis carbamic acid tert-butyl ester

C₂₈H₂₈ClN₇O₄S

Refernces

• 1、 -. "PYRAZOLOPYRIDINES AND PYRAZOLOPYRIDINES AND THEIR USE AS TYK2 INHIBITORS". Page/Page column 91-92. . Retrieved 2012/06/01.