{6-[2-(2-chloro-6-cyanophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]2-methylpyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

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Chemical Name:{6-[2-(2-chloro-6-cyanophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]2-methylpyrimidin-4-yl}-bis-carbamic acid tert-butyl ester
CAS No.:1378040-26-6
Molecular Formula:C₂₈H₂₈ClFN₈O₄
Molecular Weight:595.033
Hs Code.:

Synonyms:{6-[2-(2-chloro-6-cyanophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]2-methylpyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

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Chemical Property of {6-[2-(2-chloro-6-cyanophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]2-methylpyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

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Technology Process of {6-[2-(2-chloro-6-cyanophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]2-methylpyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

There total 11 articles about {6-[2-(2-chloro-6-cyanophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]2-methylpyrimidin-4-yl}-bis-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1364663-30-8
(6-amino-2-methylpyrimidin-4-yl)-bis-carbamic acid tert-butyl ester

: 1378040-25-5
2-(4-bromo-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3-chlorobenzonitrile

: 1378040-26-6
{6-[2-(2-chloro-6-cyanophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]2-methylpyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃; for 6h; Inert atmosphere; Sealed tube;

Reference yield:

: 2546-56-7
4-chloro-3-fluoro-pyridine

: 1378040-26-6
{6-[2-(2-chloro-6-cyanophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]2-methylpyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 18.75 h / -78 - -30 °C

1.2: 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: triethylamine; titanium tetrachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: toluene / 5 h / 105 °C

5.1: dihydrogen peroxide; methyltrioxorhenium(VII) / dichloromethane / 20 °C

6.1: trichlorophosphate / 1,2-dichloro-ethane / 4 h / 70 °C / Inert atmosphere

7.1: trimethylsilyl bromide / propiononitrile / 3.5 h / 110 °C / Inert atmosphere

8.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 6 h / 80 °C / Inert atmosphere; Sealed tube

With n-butyllithium; sodium azide; trimethylsilyl bromide; dihydrogen peroxide; titanium tetrachloride; methyltrioxorhenium(VII); caesium carbonate; triethylamine; diisopropylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; propiononitrile;

Reference yield:

: 1749-68-4
4-amino-6-chloro-2-methylpyrimidine

: 1378040-26-6
{6-[2-(2-chloro-6-cyanophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]2-methylpyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C

1.2: 18 h / 20 °C

2.1: sodium azide / dimethyl sulfoxide / 16 h / 50 °C

3.1: hydrogen / palladium on activated charcoal / ethyl acetate; industrial methylated spirits / 18 h / 20 °C

4.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 6 h / 80 °C / Inert atmosphere; Sealed tube

With sodium azide; hydrogen; caesium carbonate; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; industrial methylated spirits; dimethyl sulfoxide; ethyl acetate;