(Z)-1-[4-(2-CHLOROETHOXYPHENYL)]-1,2-DIPHENYL-1-BUTENE-4,4,5,5,5-D5

Base Information

• Chemical Name: (Z)-1-[4-(2-CHLOROETHOXYPHENYL)]-1,2-DIPHENYL-1-BUTENE-4,4,5,5,5-D5
• CAS No.: 157738-49-3
• Molecular Formula: C24H18ClD5O
• Molecular Weight: 367.92
• Mol file: 157738-49-3.mol

Synonyms:(Z)-1-[4-(2-CHLOROETHOXYPHENYL)]-1,2-DIPHENYL-1-BUTENE-4,4,5,5,5-D5;(Z)-1-(2-Chloroethoxy)-4-(1,2-diphenyl-1-butenyl-3,3,4,4,4-d5)benzene

Chemical Property of (Z)-1-[4-(2-CHLOROETHOXYPHENYL)]-1,2-DIPHENYL-1-BUTENE-4,4,5,5,5-D5

Chemical Property:

• Vapor Pressure: 1.01E-08mmHg at 25°C
• Melting Point: 103-105°C
• Boiling Point: 474.7°C at 760 mmHg
• Flash Point: 235.3°C
• PSA: 9.23000
• Density: 1.123g/cm³
• LogP: 6.67330
• Solubility.: Chloroform, Dichlormethane, Ethanol, Methanol

Purity/Quality:

97% ^*data from raw suppliers

(E/Z)-1-[4-(2-Chloroethoxyphenyl]-1,2-diphenyl-1-butene-4,4,5,5,5-d5 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the prepration of labelled Tamoxifen derivatives.

Technology Process of (Z)-1-[4-(2-CHLOROETHOXYPHENYL)]-1,2-DIPHENYL-1-BUTENE-4,4,5,5,5-D5

There total 5 articles about (Z)-1-[4-(2-CHLOROETHOXYPHENYL)]-1,2-DIPHENYL-1-BUTENE-4,4,5,5,5-D5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetic acid (103-82-2) → <3,3,4,4,4-2H5>-(Z)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene (157738-49-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 53 percent / trifluoroacetic anhydride / 24 h / Ambient temperature

2: 1.) NaH / 1.) THF, 30 min, 2.) THF, RT, 3 h

3: tetrahydrofuran; hexane / -78 - 20 °C

4: HCl, EtOH / 3 h / Heating

With hydrogenchloride; ethanol; sodium hydride; trifluoroacetic anhydride; In tetrahydrofuran; hexane;

DOI:10.1002/jlcr.2580340810

Reference yield:

1-<4-(2-chloroethoxy)phenyl>-2-phenylethanone (19561-95-6) → <3,3,4,4,4-2H5>-(Z)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene (157738-49-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, 30 min, 2.) THF, RT, 3 h

2: tetrahydrofuran; hexane / -78 - 20 °C

3: HCl, EtOH / 3 h / Heating

With hydrogenchloride; ethanol; sodium hydride; In tetrahydrofuran; hexane;

DOI:10.1002/jlcr.2580340810

Reference yield:

<3,3,4,4,4-2H5>-1-<4-(2-chloroethoxy)phenyl>-2-phenyl1-butanone (157738-48-2) → <3,3,4,4,4-2H5>-(Z)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene (157738-49-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; hexane / -78 - 20 °C

2: HCl, EtOH / 3 h / Heating

With hydrogenchloride; ethanol; In tetrahydrofuran; hexane;

DOI:10.1002/jlcr.2580340810

upstream raw materials:

phenylacetic acid

1-<4-(2-chloroethoxy)phenyl>-2-phenylethanone

<3,3,4,4,4-2H5>-1-<4-(2-chloroethoxy)phenyl>-2-phenyl1-butanone

2-chloroethoxybenzene

Downstream raw materials:

-tamoxifen