Ethyl 3-(2-BroMo-6-nitrophenyl)-2-oxopropanoate

Base Information

• Chemical Name: Ethyl 3-(2-BroMo-6-nitrophenyl)-2-oxopropanoate
• CAS No.: 608510-29-8
• Molecular Formula: C11H10BrNO5
• Molecular Weight: 316.1048
• Hs Code.: 2918300090
• Mol file: 608510-29-8.mol

Synonyms:Ethyl 3-(2-BroMo-6-nitrophenyl)-2-oxopropanoate

Chemical Property of Ethyl 3-(2-BroMo-6-nitrophenyl)-2-oxopropanoate

Chemical Property:

• Boiling Point: 404.2±35.0 °C(Predicted)
• PSA: 89.19000
• Density: 1.577±0.06 g/cm3(Predicted)
• LogP: 2.55520

Purity/Quality:

99%min ^*data from raw suppliers

Ethyl 3-(2-bromo-6-nitrophenyl)-2-oxopropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-(2-BroMo-6-nitrophenyl)-2-oxopropanoate

There total 1 articles about Ethyl 3-(2-BroMo-6-nitrophenyl)-2-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-bromo-6-nitrotoluene (55289-35-5) + oxalic acid diethyl ester (95-92-1) → ethyl 3-(2-bromo-6-nitrophenyl)-2-oxopropanoate (608510-29-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0960-894X(03)00637-1

Reference yield: 91.0%

ethyl 3-(2-bromo-6-nitrophenyl)-2-oxopropanoate (608510-29-8) → 3-(2-bromo-6-nitro-phenyl)-propane-1,2-diol (608510-30-1)

Guidance literature:

With lithium borohydride; In tetrahydrofuran;

DOI:10.1016/S0960-894X(03)00637-1

Reference yield:

ethyl 3-(2-bromo-6-nitrophenyl)-2-oxopropanoate (608510-29-8) → 3-(2-decyl-6-methylamino-phenyl)-propane-1,2-diol (608510-34-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 91 percent / LiBH₄ / tetrahydrofuran

2: 94 percent / pyridine

3: 40 percent / PdCl₂(PPh₃)2; CuI; Et₃N / tetrahydrofuran

4: H₂ / Pd/C / ethanol

5: tetrahydrofuran

6: BH₃ / tetrahydrofuran

7: NaOH / methanol

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; lithium borohydride; borane; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 3: Sonogashira coupling;

DOI:10.1016/S0960-894X(03)00637-1

upstream raw materials:

2-bromo-6-nitrotoluene

oxalic acid diethyl ester

Downstream raw materials:

6-bromo-2-nitrophenylpyruvic acid

3-(2-bromo-6-nitro-phenyl)-propane-1,2-diol

acetic acid 1-acetoxymethyl-2-(2-bromo-6-nitro-phenyl)-ethyl ester

3-(2-decyl-6-methylamino-phenyl)-propane-1,2-diol

Refernces

• 1、 Nakagawa, Yu,Irie, Kazuhiro,Yamanaka, Nobuhiro,Ohigashi, Hajime,Tsuda, Ken-Ichiro. "Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes". . p. 3015 - 3019. Retrieved 2007/10/03.