6-bromo-2-nitrophenylpyruvic acid

Base Information

• Chemical Name: 6-bromo-2-nitrophenylpyruvic acid
• CAS No.: 98592-11-1
• Molecular Formula: C₉H₆BrNO₅
• Molecular Weight: 288.054
• Mol file: 98592-11-1.mol

Synonyms:6-bromo-2-nitrophenylpyruvic acid

Chemical Property of 6-bromo-2-nitrophenylpyruvic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6-bromo-2-nitrophenylpyruvic acid

There total 5 articles about 6-bromo-2-nitrophenylpyruvic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-6-nitrotoluene (55289-35-5) → 6-bromo-2-nitrophenylpyruvic acid (98592-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1: EtOK / ethanol / Heating

2: aq. HCl

With hydrogenchloride; potassium ethoxide; In ethanol;

DOI:10.1021/jm00400a009

Reference yield:

ethyl 3-(2-bromo-6-nitrophenyl)-2-oxopropanoate (608510-29-8) → 6-bromo-2-nitrophenylpyruvic acid (98592-11-1)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jm00400a009

Reference yield:

3-nitro-o-tolylamine (603-83-8) → 6-bromo-2-nitrophenylpyruvic acid (98592-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaNO₂, HBr (48percent); 2.) CuBr, HBr (48percent) / 1.) H₂O, below 0 deg C; 2.) 90 deg C, 0.5 h

2: 1.) sodium ethoxide / 1.) overnight, room temp.; reflux, 10 min; 2.) H₂O, reflux, 2 h

With hydrogen bromide; sodium ethanolate; copper(I) bromide; sodium nitrite;

DOI:10.1248/cpb.33.1414

upstream raw materials:

2-bromo-6-nitrotoluene

oxalic acid diethyl ester

ethyl 3-(2-bromo-6-nitrophenyl)-2-oxopropanoate

3-nitro-o-tolylamine

Downstream raw materials:

4-bromo-1H-indole

4-bromoindolin-2-one

4-bromo-1H-Indole-2-carboxylic acid ethyl ester

(2-Brom-6-nitro-phenyl)-aceton