8-BroMo-iMidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester

Base Information

• Chemical Name: 8-BroMo-iMidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester
• CAS No.: 957103-97-8
• Molecular Formula: C10H9BrN2O2
• Molecular Weight: 269.098
• Hs Code.: 2933399990
• Mol file: 957103-97-8.mol

Synonyms:8-BroMo-iMidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester;ethyl 8-bromoH-imidazo[1,2-a]pyridine-6-carboxylate

Chemical Property of 8-BroMo-iMidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl 8-bromoimidazo[1,2-a]pyridine-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 8-BroMo-iMidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester

There total 4 articles about 8-BroMo-iMidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-chloroethanal (107-20-0) + 6-amino-5-bromonicotinic acid ethyl ester (850429-51-5) → 8-bromoimidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester (957103-97-8)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; water; for 17h; Reflux;

Reference yield:

1-bromo-2,2-dimethoxyethane (7252-83-7) + 6-amino-5-bromonicotinic acid ethyl ester (850429-51-5) → 8-bromoimidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester (957103-97-8)

Guidance literature:

toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 90 ℃; for 42h; Molecular sieves 4 ?;

Reference yield:

6-aminonicotinic acid (3167-49-5) → 8-bromoimidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester (957103-97-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 17 h / 60 °C / Reflux

2: N-Bromosuccinimide / tetrahydrofuran / 17 h / 0 - 23 °C

3: sodium hydrogencarbonate / water; ethanol / 17 h / Reflux

With N-Bromosuccinimide; thionyl chloride; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water;

upstream raw materials:

1-bromo-2,2-dimethoxyethane

6-amino-5-bromonicotinic acid ethyl ester

2-chloroethanal

6-aminonicotinic acid

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