3167-49-5

Basic information

• Product Name: 6-Aminonicotinic acid
• Synonyms: 3-Pyridinecarboxylic acid, 6-amino-;6-amino-3-pyridinecarboxylicaci;6-AMINONICOTINIC ACID;6-AMINOPYRIDINE-3-CARBOXYLIC ACID;2-AMINO-5-PYRIDINECARBOXYLIC ACID;2-AMINOPYRIDINE-5-CARBOXYLIC ACID;RARECHEM AL BO 1167;TIMTEC-BB SBB004186
• CAS NO: 3167-49-5
• Molecular Formula: C₆H₆N₂O₂
• Molecular Weight: 138.12
• EINECS: 221-630-4
• Product Categories: AMINOACID;Amines;blocks;Carboxes;Pyridines;Pyridine;pyridine derivative;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Pyridine series;Carboxylic Acids;Organic acids;Chemical Amines;Heterocycles;Carboxylic Acids;Aromatics
• Mol File: 3167-49-5.mol
• Article Data: 14

Chemical Properties

• Melting Point: >300 °C(lit.)
• Boiling Point: 253.51°C (rough estimate)
• Flash Point: 179.8 °C
• Appearance: White to beige/Powder
• Density: 1.3471 (rough estimate)
• Vapor Pressure: 3.03E-06mmHg at 25°C
• Refractive Index: 1.5100 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.86±0.10(Predicted)
• Water Solubility: ca 1.0 g/L (20 ºC)
• Merck: 14,456
• BRN: 115992
• CAS DataBase Reference: 6-Aminonicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Aminonicotinic acid(3167-49-5)
• EPA Substance Registry System: 6-Aminonicotinic acid(3167-49-5)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-23/24/25
• Safety Statements: 22-24/25-45-36/37/39-26
• WGK Germany: 3
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 3167-49-5(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow Cryst

Uses

Different sources of media describe the Uses of 3167-49-5 differently. You can refer to the following data:
1. 6-Aminopyridine-3-carboxylic acid (6-Aminonicotinic acid) was used in the preparation of resin-bound 2-aminoazine.
2. Antiproliferative

Definition

ChEBI: An aminonicotinic acid in which the amino group is situated at position 6 of the pyridine ring.

General Description

Electrosynthesis of 6-aminopyridine-3-carboxylic acid (6-aminonicotinic acid) by electrochemical reduction of 2-amino-5-bromo and 2-amino-5-chloropyridine in the presence of CO2 at silver electrode has been reported.

Purification Methods

Crystallise the acid from aqueous acetic acid. Dry it in vacuo at 70o. [Beilstein 22 III/IV 6726.]

InChI:InChI=1/C6H6N2O2/c7-5-2-1-4(3-8-5)6(9)10/h1-3H,(H2,7,8)(H,9,10)

Synthetic route

2,2-dimethyl-3-(5-cyanopyrid-2-yl)-4-oxo-4H-1,3-benzoxazine (74405-04-2) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
With hydrogenchloride for 6h; Heating;	88%

5-chloro-2-pyridylamine (1072-98-6) + carbon dioxide (124-38-9) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 5℃; under 760 Torr; Electrochemical reaction;	78%

6-(acetylamino)pyridine-3-carboxylic acid (21550-48-1) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
With water; sodium hydroxide for 6h; Reflux;	46%
With sodium hydroxide
Multi-step reaction with 5 steps 1: methanol; HCl 2: acetic acid 3: concentrated aqueous NH3 4: concentrated aqueous NH3 / 130 °C 5: aqueous NaOH View Scheme

ethyl-6-amino-nicotinate (39658-41-8) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
With water; sodium hydroxide In methanol at 20℃; for 18h;	33%

6-aminonicotinonitrile (4214-73-7) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
With hydrogenchloride at 160℃; im Rohr;

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
With ammonia at 170℃;

6-aminonicotinic amide (329-89-5) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
With sodium hydroxide

6-methoxycarbonylamino-nicotinic acid methyl ester → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
With hydrogenchloride; acetic acid

1-(5-Carboxy-2-pyridyl)-2-pyridon-3-carbonsaeure (117638-64-9) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
With base
With hydrogenchloride; sodium hydroxide 1.) heating; Multistep reaction;

nicotinyl 6-aminonicotinate → 3-hydroxymethylpyridin (100-55-0) + 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
With phosphate buffer In water at 65℃; Rate constant; Thermodynamic data; pH 5.17, ΔS, activation energy, other pH, solvent effect;

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) + ammonium hydroxide → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
at 170℃;

5-chloro-2-nitropyridine (52092-47-4) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: 82 percent / hydrogen; sulfuric acid / ethanol / 25 °C / Electrochemical reaction 2: 78 percent / Bu4NI / dimethylformamide / 5 °C / 760 Torr / Electrochemical reaction View Scheme

nicotinic acid (59-67-6) + phenyl-β-pyridyl ketone → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: 80 percent / 30percent H2O2 / acetic acid / 3 h / 90 °C 3: base View Scheme

Nicotinic acid N-oxide (2398-81-4) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 2 steps 2: base View Scheme
Multi-step reaction with 2 steps 1: POCl3 / dimethylformamide 2: 1.) conc. NaOH solution, 2.) aq. HCl / 1.) heating View Scheme

3-cyanopyridine N-oxide (14906-64-0) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: 23 percent / CHCl3 / 4 h / Heating 2: 88 percent / conc. HCl / 6 h / Heating View Scheme

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: acetic acid 2: aqueous KMnO4 3: aqueous NaOH View Scheme
Multi-step reaction with 7 steps 1: acetic acid 2: aqueous KMnO4 3: methanol; HCl 4: acetic acid 5: concentrated aqueous NH3 6: concentrated aqueous NH3 / 130 °C 7: aqueous NaOH View Scheme

N-(5-methylpyridin-2-yl)acetamide (4931-47-9) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous KMnO4 2: aqueous NaOH View Scheme
Multi-step reaction with 6 steps 1: aqueous KMnO4 2: methanol; HCl 3: acetic acid 4: concentrated aqueous NH3 5: concentrated aqueous NH3 / 130 °C 6: aqueous NaOH View Scheme

methyl 6-aminonicotinoate (36052-24-1) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 4 steps 1: acetic acid 2: concentrated aqueous NH3 3: concentrated aqueous NH3 / 130 °C 4: aqueous NaOH View Scheme

6-acetamide-nicotinic acid methyl ester (98953-23-2) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: concentrated aqueous NH3 2: concentrated aqueous NH3 / 130 °C 3: aqueous NaOH View Scheme

dimethyl 2,5-pyridine dicarboxylate (881-86-7) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 4 steps 1: methanol; N2H4+H2O 2: aqueous HCl; aqueous NaNO2 3: methanol 4: acetic acid; concentrated aqueous HCl View Scheme

6-hydrazinocarbonyl-nicotinic acid methyl ester (512782-63-7) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: aqueous HCl; aqueous NaNO2 2: methanol 3: acetic acid; concentrated aqueous HCl View Scheme

6-azidocarbonyl-nicotinic acid methyl ester → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol 2: acetic acid; concentrated aqueous HCl View Scheme

6-acetylamino-nicotinic acid amide (77837-05-9) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: concentrated aqueous NH3 / 130 °C 2: aqueous NaOH View Scheme

6-chloro-3-pyridinecarboxamide (6271-78-9) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: concentrated aqueous NH3 / 170 °C 2: aqueous NaOH View Scheme

6-hydroxy-3-pyridinecarboxylic acid (5006-66-6) + acetonitrile (75-05-8) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
With potassium hydroxide; acetic anhydride; triethylamine

benzyl 6-aminopyridine-3-carboxylate (935687-49-3) → 6-aminonicotinic acid (3167-49-5)

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃;

6-aminonicotinic acid (3167-49-5) + potassium 2-chloro-3-ethoxy-3-oxoprop-1-en-1-olate → imidazo[1,2-a]pyridine-3,6-dicarboxylic acid ethyl ester (936637-98-8)

Conditions	Yield
With sulfuric acid In ethanol at 0℃; for 18h; Heating / reflux;	100%

methanol (67-56-1) + 6-aminonicotinic acid (3167-49-5) → methyl 6-aminonicotinoate (36052-24-1)

Conditions	Yield
With hydrogenchloride for 18h; Reflux;	98%
With thionyl chloride at 80℃; for 12h; Inert atmosphere;	89%
With sulfuric acid at 0 - 80℃;	81.5%

6-aminonicotinic acid (3167-49-5) + ethanol (64-17-5) → ethyl-6-amino-nicotinate (39658-41-8)

Conditions	Yield
Stage #1: 6-aminonicotinic acid; ethanol With thionyl chloride for 72h; Heating; Stage #2: With sodium hydroxide In methanol for 1h;	97%
Stage #1: 6-aminonicotinic acid; ethanol With thionyl chloride at 60℃; for 18h; Heating / reflux; Stage #2: With sodium hydrogencarbonate	95.8%
Stage #1: 6-aminonicotinic acid; ethanol With thionyl chloride at 0℃; Reflux; Stage #2: With sodium carbonate In water pH=9;	94%

6-aminonicotinic acid (3167-49-5) + 1-amino-4-[(tert-butyloxycarbonyl)amino]butane (68076-36-8) → tert-butyl (4-(6-aminonicotinamido)butyl)carbamate

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	97%

6-aminonicotinic acid (3167-49-5) + orthoformic acid triethyl ester (122-51-0) → 6-(1H-tetrazol-1-yl)nicotinic acid (299918-69-7)

Conditions	Yield
With sodium azide In neat (no solvent) at 90℃; for 0.7h; Reagent/catalyst; Green chemistry;	95%

6-aminonicotinic acid (3167-49-5) + acetic anhydride (108-24-7) → 6-(acetylamino)pyridine-3-carboxylic acid (21550-48-1)

Conditions	Yield
In pyridine at 130℃; for 24h; Acetylation;	92%
With pyridine at 130℃; for 16h;	71%
With pyridine at 20 - 130℃;	49%
With pyridine at 140℃; for 24h; Acidic aqueous solution;	26%
With pyridine at 20 - 80℃; for 72h;	22%

6-aminonicotinic acid (3167-49-5) → ethyl-6-amino-nicotinate (39658-41-8)

Conditions	Yield
In ethanol	92%
In hydrogenchloride; ethanol; ethyl acetate

6-aminonicotinic acid (3167-49-5) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 6-amino-N-methoxy-N-methylpyridine-3-carboxamide (1097210-47-3)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	92%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃;
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h;	0.61 g

6-aminonicotinic acid (3167-49-5) + N-(tert-butoxycarbonyl)-1,7-heptanediamine (99733-18-3) → tert-butyl (7-(6-aminonicotinamido)heptyl)carbamate

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	91%

6-aminonicotinic acid (3167-49-5) → 6-aminonicotinic acid monophosphate

Conditions	Yield
With phosphoric acid In methanol at 20℃; for 0.333333h;	90%

6-aminonicotinic acid (3167-49-5) → 2-amino-3,4,5,6-tetrahydropyridine-5-carboxylic acid hydrochloride

Conditions	Yield
With hydrogenchloride; hydrogen; platinum(IV) oxide In ethanol under 1499.7 Torr; for 2h; Ambient temperature;	89.7%

6-aminonicotinic acid (3167-49-5) + (E)-diethyl 1-((4,8-dimethylnona-3,7-dienyl)(ethoxy)phosphoryl)vinylphosphonate (1240313-14-7) → C25H42N2O7P2 (1240313-16-9)

Conditions	Yield
In toluene at 50℃; for 5h;	85%

6-aminonicotinic acid (3167-49-5) + 2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide (1246246-70-7) → 6-amino-N-(3-[(([(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy)acetyl)(methyl)amino]propyl)-N-methylnicotinamide (1246246-89-8)

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 20℃;	85%

6-aminonicotinic acid (3167-49-5) → 6-amino-nicotinic acid ; nitrate

Conditions	Yield
With nitric acid In methanol at 20℃; for 0.333333h;	85%

4-ethylpiperazine (5308-25-8) + 6-aminonicotinic acid (3167-49-5) → (6-aminopyridin-3-yl)(4-ethylpiperazin-1-yl)methanone

Conditions	Yield
Stage #1: 6-aminonicotinic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 70℃; for 1.16667h; Stage #2: 4-ethylpiperazine In N,N-dimethyl-formamide at 20℃;	85%
Stage #1: 6-aminonicotinic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20 - 70℃; for 1.16667h; Stage #2: 4-ethylpiperazine In N,N-dimethyl-formamide at 20℃;	85%

6-aminonicotinic acid (3167-49-5) + N-Boc-1,3-diaminopropane (75178-96-0) → tert-butyl (3-(6-aminonicotinamido)propyl)carbamate

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	85%

6-aminonicotinic acid (3167-49-5) + tert-butyl N-(6-aminohexyl)carbamate (51857-17-1) → tert-butyl (6-(6-aminonicotinamido)hexyl)carbamate

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	85%

2-chloroethanal (107-20-0) + 6-aminonicotinic acid (3167-49-5) → imidazo[1,2-a]pyridin-6-carboxylic acid hydrochloride salt (1314777-15-5)

Conditions	Yield
In ethanol for 8h; Reflux;	82%
In ethanol for 8h; Reflux;	82%
In ethanol for 8h; Reflux;	82%
In ethanol for 8h; Reflux;	82%

2-chloroethanal (107-20-0) + 6-aminonicotinic acid (3167-49-5) → imidazo[1,2-a]pyridine-6-carboxylic acid hydrochloride

Conditions	Yield
In ethanol for 8h; Reflux;	82%
In ethanol for 8h; Reflux;	82%

6-aminonicotinic acid (3167-49-5) + 1,3,5-triethyl-2,4,6-tris(aminomethyl)benzene (149525-65-5) → C33H39N9O3

Conditions	Yield
Stage #1: 6-aminonicotinic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In N,N-dimethyl-formamide for 0.0833333h; Stage #2: 1,3,5-triethyl-2,4,6-tris(aminomethyl)benzene With triethylamine In dichloromethane at 20℃; for 2h;	82%

6-aminonicotinic acid (3167-49-5) + (1R,3S)-N1-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-yl)cyclohexane-1,3-diamine hydrochloride → 6-amino-N-((1S,3R)-3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)nicotinamide

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 24h;	81%

6-aminonicotinic acid (3167-49-5) → C6H6N2O2*BrH

Conditions	Yield
With hydrogen bromide In methanol at 20℃; for 0.333333h;	80%

6-aminonicotinic acid (3167-49-5) + 6,6-difluoro-5-methyl-5-hexenyl methanesulfonate (509101-25-1) → 6,6-difluoro-5-methyl-5-hexenyl 6-aminonicotinate

Conditions	Yield
With sodium hydrogencarbonate In DMF (N,N-dimethyl-formamide) at 100℃; for 3h;	78%

6-aminonicotinic acid (3167-49-5) → 6-[2-(2-benzyl-3-oxo-2,3-dihydro-1H-isoindol-1-ylsulfanyl)-acetylamino]-nicotinic acid

Conditions	Yield
Stage #1: 3-(carboxymethylthio)-2,3-dihydro-2-(phenylmethyl)-1H-isoindol-1-one With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 0.5h; Stage #2: 6-aminonicotinic acid With pyridine In tetrahydrofuran; dichloromethane at 20℃; for 4h;	77%

morpholine (110-91-8) + 6-aminonicotinic acid (3167-49-5) → (6-aminopyridin-3-yl)(morpholin-4-yl)methanone (827587-90-6)

Conditions	Yield
Stage #1: 6-aminonicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 1.5h; Stage #2: morpholine With pyridine In dichloromethane at 0 - 20℃; Stage #3: With ethylenediamine In ethanol; dichloromethane for 0.5h; Reflux;	72.5%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	66%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In ethanol for 18h;	30%

6-aminonicotinic acid (3167-49-5) + 1-methyl-2-(methylaminomethyl)-1H-indole (3514-15-6) → 6-amino-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-nicotinamide

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In dichloromethane; N,N-dimethyl-formamide for 16h;	72%

6-aminonicotinic acid (3167-49-5) → (6-amino-3-pyridinyl)methanol (113293-71-3)

Conditions	Yield
Stage #1: 6-aminonicotinic acid With ethanol; sulfuric acid for 16h; Heating / reflux; Stage #2: With sodium carbonate In ethanol; water Stage #3: With sodium hydroxide; lithium aluminium tetrahydride; water more than 3 stages;	72%
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃;
Stage #1: 6-aminonicotinic acid With borane-THF In tetrahydrofuran for 4h; Heating / reflux; Stage #2: With hydrogenchloride; methanol; water In tetrahydrofuran at 80℃; for 1h; Stage #3: With sodium hydroxide; water In tetrahydrofuran; methanol

6-aminonicotinic acid (3167-49-5) + tert-butylamine (75-64-9) → C10H15N3O

Conditions	Yield
Stage #1: 6-aminonicotinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.25h; Stage #2: tert-butylamine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 4h;	71%

Upstream product

• 4214-73-7 6-aminonicotinonitrile 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 21550-48-1 6-(acetylamino)pyridine-3-carboxylic acid 
• 881-86-7 dimethyl 2,5-pyridine dicarboxylate 
• 329-89-5 6-aminonicotinic amide 
• 39658-41-8 ethyl-6-amino-nicotinate 
• 935687-49-3 benzyl 6-aminopyridine-3-carboxylate 
• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 75-05-8 acetonitrile 
• 6271-78-9 6-chloro-3-pyridinecarboxamide 
• 77837-05-9 6-acetylamino-nicotinic acid amide 
• 512782-63-7 6-hydrazinocarbonyl-nicotinic acid methyl ester 
• 98953-23-2 6-acetamide-nicotinic acid methyl ester 
• 36052-24-1 methyl 6-aminonicotinoate 

Downstream Products

• 39658-41-8 ethyl-6-amino-nicotinate 
• 33225-73-9 6-nitronicotinic acid 
• 89488-06-2 5-nitro-6-aminonicotinic acid 
• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 42596-56-5 6-amino-nicotinic acid hydrazide 
• 36052-24-1 methyl 6-aminonicotinoate 
• 935687-49-3 benzyl 6-aminopyridine-3-carboxylate 
• 543740-75-6 6-amino-5-iodonicotinic acid ethyl ester 
• 850429-51-5 6-amino-5-bromonicotinic acid ethyl ester 
• 957103-97-8 8-bromoimidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester 

Relevant articles and documents

Electrocatalytic carboxylation of 2-amino-5-bromopyridine with CO 2 in ionic liquid 1-butyl-3-methyllimidazoliumtetrafluoborate to 6-aminonicotinic acid

A new electrochemical procedure for the electrocatalytic carboxylation of 2-amino-5-bromopyridine with CO2 in ionic liquid, 1-butyl-3-methyllimidazolium tetrafluoborate (BMIMBF4), to 6-aminonicotinic acid was investigated for the first time. The experiments were carried out in three electrodes undivided cell under mild conditions, and the use of volatile and toxic solvents and catalysts, as well as any other additional supporting electrolytes, was avoided. The electrochemical reduction behavior of 2-amino-5-bromopyridine in BMIMBF4 had been studied by cyclic voltammetry with a reduction peak at-1.6V (vs. Ag). 6-Aminonicotinic acid was obtained in 75% yield and 100% selectivity, under the optimized condition. Moreover, the ionic liquid was successfully recycled.

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Substituted cinnamamide compounds and analogs, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or ameliorate cancer are provided.

Electroorganic synthesis of 6-aminonicotinic acid from 2-amino-5-chloropyridine

A synthesis of 6-aminonicotinic acid by electrochemical hydrogenation of 5-chloro-2-nitropyridine and electrochemical carboxylation of 2-amino-5-chloropyridine at a cathode surface in the presence of sulphuric acid and carbon dioxide in a dimethylformamide (DMF) solution at an apparent current density of 10 mA/cm2 using an undivided cell with good yields is reported.