4-Chloro-2-hydroxyphenylboronic acid

Base Information

• Chemical Name: 4-Chloro-2-hydroxyphenylboronic acid
• CAS No.: 1238196-66-1
• Molecular Formula: C6H6BClO3
• Molecular Weight: 172.376
• Hs Code.: 2931900090
• Mol file: 1238196-66-1.mol

Synonyms:4-Chloro-2-hydroxyphenylboronic acid

Chemical Property of 4-Chloro-2-hydroxyphenylboronic acid

Chemical Property:

• Boiling Point: 346.6±52.0 °C(Predicted)
• PKA: 8.47±0.58(Predicted)
• PSA: 60.69000
• Density: 1.49±0.1 g/cm3(Predicted)
• LogP: -0.27460

Purity/Quality:

99%,98%, ^*data from raw suppliers

4-Chloro-2-hydroxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Chloro-2-hydroxyphenylboronic acid

There total 2 articles about 4-Chloro-2-hydroxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(4-chloro-2-methoxyphenyl)boronic acid (762287-57-0) → (4-chloro-2-hydroxyphenyl)boronic acid (1238196-66-1)

Guidance literature:

(4-chloro-2-methoxyphenyl)boronic acid; With boron tribromide; In dichloromethane; at 20 ℃; for 1h;

With water; In dichloromethane;

Reference yield:

Triisopropyl borate (5419-55-6) + 2-bromo-4-chlorophenol (695-96-5) + water (7732-18-5) → (4-chloro-2-hydroxyphenyl)boronic acid (1238196-66-1)

Guidance literature:

2-bromo-4-chlorophenol; With n-butyllithium; In diethyl ether; at -78 ℃; Inert atmosphere; Schlenk technique;

Triisopropyl borate; Inert atmosphere; Schlenk technique;

water; With hydrogenchloride; Inert atmosphere; Schlenk technique;

DOI:10.1021/om301057d

Reference yield: 97.0%

(4-chloro-2-hydroxyphenyl)boronic acid (1238196-66-1) + tert-butyl N-(2-{6-bromoimidazo[1,2-a]pyridin-3-yl}ethyl)carbamate → tert-butyl N-{2-[6-(4-chloro-2-hydroxyphenyl )imidazo[1,2-a]pyridin-3-yl]ethyl}carbamate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 3h; Inert atmosphere;

upstream raw materials:

(4-chloro-2-methoxyphenyl)boronic acid

Triisopropyl borate

2-bromo-4-chlorophenol

water

Downstream raw materials:

5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

C₁₃H₁₀ClNO₂

C₂₅H₂₇ClN₂O

[2-(4′-Cl-C₆H₃-2′-O)-6-{CMe₂N(2″,6″-i-Pr₂C₆H₃)}C₅H₃N]AlMe(acetonitrile)

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