5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Base Information

Chemical Name:5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
CAS No.:1377503-12-2
Molecular Formula:C₁₂H₁₆BClO₃
Molecular Weight:254.521
Hs Code.:
Mol file:1377503-12-2.mol

Synonyms:5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Suppliers and Price of 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-2-hydroxyphenylboronicacidpinacolester
500mg
$ 200.00

Crysdot
5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 97%
10g
$ 1337.00

Crysdot
5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 97%
5g
$ 832.00

Crysdot
5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 97%
1g
$ 277.00

Chemenu
5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 97%
1g
$ 193.00

AOBChem
5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 97%
10g
$ 1400.00

Ambeed
5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 97%
250mg
$ 96.00

Ambeed
5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 97%
100mg
$ 49.00

Alichem
5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
10g
$ 1390.50

Alichem
5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
5g
$ 840.00

Total 11 raw suppliers

Chemical Property of 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Chemical Property:

Boiling Point:342.9±32.0 °C(Predicted)
PKA:9.12±0.40(Predicted)
Density:1.19±0.1 g/cm3(Predicted)
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-2-hydroxyphenylboronicacidpinacolester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-Chloro-2-hydroxyphenylboronic acid pinacol ester is a building block which has seen use in the preparation of 5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-ylacetic acid derivs. for treatment of HIV infection, and in the preparation of disubstituted pyridazine analogs useful in the treatment of SMN deficiency related diseases.

Technology Process of 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

There total 6 articles about 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 108-43-0
3-monochlorophenol

: 73183-34-3
bis(pinacol)diborane

: 1377503-12-2
5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: C₁₈H₂₇B₂ClO₅

Guidance literature:: 3-monochlorophenol; bis(pinacol)diborane; With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; triethylamine; 4,4'-di-tert-butyl-2,2'-bipyridine; In toluene; at 80 ℃; for 2h; Glovebox; Sealed tube;

With 2,3-dimethyl-2,3-butane diol; In chloroform; at 20 ℃; for 0.666667h;
DOI:10.1021/jacs.7b02232

Reference yield:

: 13659-23-9
2-Bromo-5-chlorophenol

: 73183-34-3
bis(pinacol)diborane

: 1377503-12-2
5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 75 - 90 ℃; for 16h; Inert atmosphere;