SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl-

Base Information

Chemical Name:SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl-
CAS No.:1393813-42-7
Molecular Formula:C13H14BrClN4O2S
Molecular Weight:405.703
Hs Code.:
Mol file:1393813-42-7.mol

Synonyms:SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl-;N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl-SulfaMide;N-(5-(4-bromophenyl)-6-chloropyrimidin-4-yl)propane-1-sulfamide

Suppliers and Price of SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[5-(4-Bromophenyl)-6-chloro-4-pyrimidinyl]-N''-propylsulfamide
100mg
$ 200.00

Medical Isotopes, Inc.
N-[5-(4-Bromophenyl)-6-chloro-4-pyrimidinyl]-N?-propylsulfamide
10 mg
$ 475.00

Medical Isotopes, Inc.
N-[5-(4-Bromophenyl)-6-chloro-4-pyrimidinyl]-N?-propylsulfamide
50 mg
$ 410.00

Ambeed
N-[5-(4-Bromophenyl)-6-chloro-4-pyrimidinyl]-N'-propylsulfamide 97%
1g
$ 111.00

Ambeed
N-[5-(4-Bromophenyl)-6-chloro-4-pyrimidinyl]-N'-propylsulfamide 97%
250mg
$ 40.00

Ambeed
N-[5-(4-Bromophenyl)-6-chloro-4-pyrimidinyl]-N'-propylsulfamide 97%
100mg
$ 25.00

Total 42 raw suppliers

Chemical Property of SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl-

Chemical Property:

Boiling Point:518.2±60.0 °C(Predicted)
PKA:4.75±0.50(Predicted)
PSA：92.36000
Density:1.612±0.06 g/cm3(Predicted)
LogP:4.76050
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

HPLC>98% ^*data from raw suppliers

N-[5-(4-Bromophenyl)-6-chloro-4-pyrimidinyl]-N''-propylsulfamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-[5-(4-Bromophenyl)-6-chloro-4-pyrimidinyl]-N''-propylsulfamide is a useful synthetic intermediate in the synthesis of Macitentan (M105005); an orally active, potent dual endothelin receptor antagonist used for pulmonary arterial hypertension.

Technology Process of SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl-

There total 8 articles about SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 146533-41-7
5-(4-bromophenyl)-4,6-dichloropyrimidine

: 147962-41-2
N-propylaminosulfonamide

: 1393813-42-7
N-5-(4-bromophenyl)-6-chloro-4-pyrimidinyl-N‘-propylsulfamide

Guidance literature:: N-propylaminosulfonamide; With potassium tert-butylate; In dimethyl sulfoxide; at 5 - 20 ℃; for 0.5h;

5-(4-bromophenyl)-4,6-dichloropyrimidine; In dimethyl sulfoxide; at 50 ℃; for 1h;

Reference yield: 86.0%

: 146533-41-7
5-(4-bromophenyl)-4,6-dichloropyrimidine

: potassium (N-propylsulfamoyl)amide

: 1393813-42-7
N-5-(4-bromophenyl)-6-chloro-4-pyrimidinyl-N‘-propylsulfamide

Guidance literature:: In N,N-dimethyl-formamide; at 70 ℃; for 4h; Inert atmosphere;

Reference yield: 85.0%

: 146533-41-7
5-(4-bromophenyl)-4,6-dichloropyrimidine

: 147962-41-2
N-propylaminosulfonamide

: 1393813-42-7
N-5-(4-bromophenyl)-6-chloro-4-pyrimidinyl-N‘-propylsulfamide

: C₁₆H₂₃BrN₆O₄S₂

Guidance literature:: 5-(4-bromophenyl)-4,6-dichloropyrimidine; With potassium carbonate; In acetonitrile; at 50 ℃; for 0.333333h; Green chemistry;

N-propylaminosulfonamide; In acetonitrile; at 50 ℃; for 10h; Reagent/catalyst; Solvent; Temperature; Green chemistry;
DOI:10.1080/00304948.2017.1320921