(3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate

Base Information

Chemical Name:(3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate
CAS No.:870640-64-5
Molecular Formula:C₂₁H₃₅NO₃
Molecular Weight:349.514
Hs Code.:
Mol file:870640-64-5.mol

Synonyms:(3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate

Suppliers and Price of (3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate

Chemical Property:

PSA：38.77000
LogP:4.27990

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate

There total 14 articles about (3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 870640-61-2
(2S,3S)-N-benzyl-1,1-dimethoxy-N,3-dimethylpentan-2-amine

: 74786-02-0
1-(tert-butyldimethylsilyloxy)-1-tert-butoxyethylene

: 870640-64-5
tert-butyl (3R,4S,5S)-4-[benzyl(methyl)amino]-3-methoxy-5-methyl heptanoate

Guidance literature:: With boron trifluoride diethyl etherate; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 24.25h;

Reference yield: 91.0%

: (2S,3S)-N-benzyl-1,1-dimethoxy-N,3-dimethylpentan-2-amine

: 74786-02-0
1-(tert-butyldimethylsilyloxy)-1-tert-butoxyethylene

: 870640-64-5
tert-butyl (3R,4S,5S)-4-[benzyl(methyl)amino]-3-methoxy-5-methyl heptanoate

Guidance literature:: With trifluoroborane diethyl ether; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 24h; Inert atmosphere;

Reference yield:

: 100-52-7
benzaldehyde

: 870640-64-5
tert-butyl (3R,4S,5S)-4-[benzyl(methyl)amino]-3-methoxy-5-methyl heptanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / water / 0.5 h / 20 °C

2.1: sodium tetrahydroborate; water / 4 h / 5 - 20 °C

3.1: formic acid / water / 3 h / 90 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 65 °C / Inert atmosphere

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -70 °C / Inert atmosphere

5.2: 1 h / -70 - -50 °C / Inert atmosphere

6.1: sulfuric acid / methanol / 0.5 h / 0 °C

6.2: 3 h / 0 - 20 °C

7.1: boron trifluoride diethyl etherate / dichloromethane; N,N-dimethyl-formamide / 24 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; lithium aluminium tetrahydride; formic acid; oxalyl dichloride; sulfuric acid; boron trifluoride diethyl etherate; water; dimethyl sulfoxide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;