Piroxicam-d3

Base Information

• Chemical Name: Piroxicam-d3
• CAS No.: 942047-64-5
• Molecular Formula: C₁₅H₁₃N₃O₄S
• Molecular Weight: 334.328
• Mol file: 942047-64-5.mol

Synonyms:4-Hydroxy-2-(methyl-d3)-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide;Artroxicam-d3;Baxo-d3;Bruxicam-d3;Caliment-d3;CHF 1251-d3;CP 16171-d3;Piroxicam-d3

Chemical Property of Piroxicam-d3

Chemical Property:

• Melting Point: 193-195°C
• PSA: 111.47000
• Density: 1.577g/cm³
• LogP: 3.24920
• Storage Temp.: -20°C Freezer

Purity/Quality:

99%+, ^*data from raw suppliers

Piroxicam-d3 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Piroxicam-d3 is a cyclooxygenase inhibitor, Clinically useful NSAID.

Technology Process of Piroxicam-d3

There total 4 articles about Piroxicam-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.5%

2-aminopyridine (504-29-0) + 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxide-d3 (942047-62-3) → piroxicam-d3 (942047-64-5)

Guidance literature:

In m-xylene; for 24h; Heating;

DOI:10.1002/jlcr.1261

Reference yield:

methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide (6639-62-9) → piroxicam-d3 (942047-64-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 64.2 percent / MeONa / dimethylsulfoxide / 0.07 h / 30 °C

2: 52.6 percent / aq. NaOH / ethanol / 24 h

3: 68.5 percent / m-xylene / 24 h / Heating

With sodium hydroxide; sodium methylate; In ethanol; dimethyl sulfoxide; m-xylene;

DOI:10.1002/jlcr.1261

Reference yield:

methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-14-9) → piroxicam-d3 (942047-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 52.6 percent / aq. NaOH / ethanol / 24 h

2: 68.5 percent / m-xylene / 24 h / Heating

With sodium hydroxide; In ethanol; m-xylene;

DOI:10.1002/jlcr.1261

upstream raw materials:

2-aminopyridine

2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxide-d3

methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide

methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

Refernces