(1R,2S)-ethyl 1-((1R,2R,4S)-2-(hex-5-en-1-yl(Methyl)carbaMoyl)-4-hydroxycyclopentanecarboxaMido)-2-vinylcyclopropanecarboxylate

Base Information

Chemical Name:(1R,2S)-ethyl 1-((1R,2R,4S)-2-(hex-5-en-1-yl(Methyl)carbaMoyl)-4-hydroxycyclopentanecarboxaMido)-2-vinylcyclopropanecarboxylate
CAS No.:922727-93-3
Molecular Formula:C22H34N2O5
Molecular Weight:406.522
Hs Code.:
Mol file:922727-93-3.mol

Synonyms:(1R,2S)-ethyl 1-((1R,2R,4S)-2-(hex-5-en-1-yl(Methyl)carbaMoyl)-4-hydroxycyclopentanecarboxaMido)-2-vinylcyclopropanecarboxylate;(1S,2R)-ethyl 1-((1R,2R,4S)-2-(hex-5-enyl(Methyl)carbaMoyl)-4-hydroxycyclopentanecarboxaMido)-2-vinylcyclopropanecarboxylate;(1R,2S)-2-Ethenyl-1-[[[(1R,2R,4S)-2-[(5-hexen-1-ylmethylamino)carbonyl]-4-hydroxycyclopentyl]carbonyl]amino]cyclopropanecarboxylic acid ethyl ester;(1R,2S)-1-{[(1R,2R,4S)-2-(hex-5-enyl-methyl-carbamoyl)-4-hydroxy-cyclopentanecarbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

Suppliers and Price of (1R,2S)-ethyl 1-((1R,2R,4S)-2-(hex-5-en-1-yl(Methyl)carbaMoyl)-4-hydroxycyclopentanecarboxaMido)-2-vinylcyclopropanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 8 raw suppliers

Chemical Property of (1R,2S)-ethyl 1-((1R,2R,4S)-2-(hex-5-en-1-yl(Methyl)carbaMoyl)-4-hydroxycyclopentanecarboxaMido)-2-vinylcyclopropanecarboxylate

Chemical Property:

Boiling Point:601.2±55.0 °C(Predicted)
PKA:13.21±0.40(Predicted)
PSA：95.94000
Density:1.14±0.1 g/cm3(Predicted)
LogP:2.20310

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1R,2S)-ethyl 1-((1R,2R,4S)-2-(hex-5-en-1-yl(Methyl)carbaMoyl)-4-hydroxycyclopentanecarboxaMido)-2-vinylcyclopropanecarboxylate

There total 10 articles about (1R,2S)-ethyl 1-((1R,2R,4S)-2-(hex-5-en-1-yl(Methyl)carbaMoyl)-4-hydroxycyclopentanecarboxaMido)-2-vinylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 259214-54-5,259214-56-7
ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride

: 922727-92-2
(1R,2R,4R)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-hydroxycyclopentane carboxylic acid

: 922727-93-3
(1R,2S)-1-{[(1R,2R,4S)-2-(hex-5-enyl-methyl-carbamoyl)-4-hydroxy-cyclopentanecarbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride; (1R,2R,4R)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-hydroxycyclopentane carboxylic acid; With HATU; at 0 ℃; Neat (no solvent);

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3.5h;

Reference yield: 60.0%

: 259214-54-5,259214-56-7
ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride

: 862174-98-9
(1R,4R,5R)-N-(hex-5-en-1-yl)-N-methyl-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxamide

: 922727-93-3
(1R,2S)-1-{[(1R,2R,4S)-2-(hex-5-enyl-methyl-carbamoyl)-4-hydroxy-cyclopentanecarbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: (1R,4R,5R)-N-(hex-5-en-1-yl)-N-methyl-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxamide; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 0 ℃;

ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2008.07.088

Reference yield:

: 862174-60-5
(1R,4R,5R)-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid

: 922727-93-3
(1R,2S)-1-{[(1R,2R,4S)-2-(hex-5-enyl-methyl-carbamoyl)-4-hydroxy-cyclopentanecarbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5.67 h / 0 - 20 °C

2.1: lithium hydroxide; water / 1 h / 0 °C

2.2: pH 2 - 3

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3.5 h / 0 - 20 °C

With lithium hydroxide; water; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;